ArticlePloS one2018
Associations between structure and function are different in healthy and glaucomatous eyes.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Performance of General-Purpose Vision Language Models and Ophthalmology Foundation Models in Glaucoma Detection and Function Prediction.Translational vision science & technology · 2025Article
- Optic Nerve Morphology Influences Structure-Function Relationship in Early Glaucoma With and Without High Myopia.Investigative ophthalmology & visual science · 2025Article
- Deep Learning Estimation of 10-2 Visual Field Map Based on Circumpapillary Retinal Nerve Fiber Layer Thickness Measurements.American journal of ophthalmology · 2023Article
- Correlation Between Enlargement of Retinal Nerve Fiber Defect Angle in En Face Imaging and Visual Field Progression.Translational vision science & technology · 2022Article
- Optical coherence tomography indices in the diagnosis and discrimination of stages of primary open-angle glaucoma in an African population.International ophthalmology · 2021Article
- LncRNA MALAT1 Accelerates Cervical Carcinoma Proliferation by Suppressing miR-124 Expression in Cervical Tumor Cells.Journal of oncology · 2021Article
- Deep Learning Approaches Predict Glaucomatous Visual Field Damage from OCT Optic Nerve Head En Face Images and Retinal Nerve Fiber Layer Thickness Maps.Ophthalmology · 2020Article
- Transcription Factor p53 Suppresses Tumor Growth by Prompting Pyroptosis in Non-Small-Cell Lung Cancer.Oxidative medicine and cellular longevity · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo assess if there are differences in the structure-function associations between healthy and glaucomatous eyes.
methodsStructure-function associations were assessed in healthy and glaucomatous eyes in three datasets, globally and in the six sectors of the optic nerve head. Structural parameters included rim area (RA) and retinal nerve fiber layer thickness (RNFLT). Functional parameters included unweighted mean of sensitivity thresholds (MS) and unweighted mean of total deviation values (MD), assessed with standard automated perimetry, short-wavelength automated perimetry, frequency-doubling technology perimetry, or contrast sensitivity perimetry. All structural and functional parameters were expressed as percent of mean normal. SF associations were assessed with correlation analyses (Pearson, Spearman and Kendall). We also assessed the SF associations with linear regression analyses: the generalized estimating equation (GEE) was used to adjust for inter-eye correlations and ordinary least squares (OLS) linear models were used when these adjustments were not necessary. We applied Bonferroni corrections to adjust for the impact of multiple comparisons.
resultsOverall, none of the Pearson correlations tested in healthy eyes were significant (correlations ranged from -0.17 to 0.37), whereas 77% of the correlations tested in glaucomatous eyes were significant (correlations ranged from 0.01 to 0.79). Similarly, none of the slopes obtained with GEE and OLS were significant in healthy eyes (slopes ranged from -0.30 to 0.87), whereas 82% of the slopes obtained in glaucomatous eyes were significant (slopes ranged from 0.02 to 1.38).
conclusionsSignificant associations between structure and function were consistently observed in glaucomatous eyes, but not in healthy eyes. These differences in association should be considered in the design of structure-function models for progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.