ArticlePloS one2018
Factors associated with the presentation of erosive esophagitis symptoms in health checkup subjects: A prospective, multicenter cohort study.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 19 citations in OpenAlex.
- Laryngopharyngeal Reflux: The Impact of Obesity.World journal of otorhinolaryngology - head and neck surgery · 2025Article
- Accuracy of COuGH RefluX Score as a Predictor of Gastroesophageal Reflux Disease (GERD) in Mexican Patients with Chronic Laryngopharyngeal Symptoms: A Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2025Article
- Asymptomatic Erosive Esophagitis.Digestive diseases and sciences · 2025Review
- The prevalence, severity, and risk factors of erosive esophagitis in a Middle Eastern population.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2024Article
- Factors Associated with Overlap between Functional Dyspepsia and Nonerosive Reflux Disease in Endoscopy-based Helicobacter pylori-uninfected Japanese Health Checkup Participants: A Prospective, Multicenter Cross-sectional Study.Internal medicine (Tokyo, Japan) · 2024Article
- Lifestyle- and comorbidity-related factors for the prescription of proton pump inhibitors afterJGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Study on the relationship of depression, anxiety, lifestyle and eating habits with the severity of reflux esophagitis.BMC gastroenterology · 2021Article
- Extra-esophageal symptoms in individuals with and without erosive esophagitis: a case-control study in Albania.BMC gastroenterology · 2021Article
- Dietary and Lifestyle Factors Related to Gastroesophageal Reflux Disease: A Systematic Review.Therapeutics and clinical risk management · 2021Review
- Erosive Esophagitis Portends a Benign Clinical Course in the Majority of Patients.Digestive diseases and sciences · 2020Article
- Influence of sex on the association between body mass index and frequency of upper gastrointestinal symptoms.JGH open : an open access journal of gastroenterology and hepatology · 2020Article
- Evidence-Based Practice Guideline for Surgical Treatment of Gastroesophageal Reflux Disease 2018.Journal of gastric cancer · 2018Review
- Lifestyle Factors Associated With Erosive Esophagitis in Japanese Individuals With and Without Obesity Undergoing Health Checkups.Journal of primary care & community healthArticle
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Authors and funding
16 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to clarify the factors associated with the presentation of erosive esophagitis (EE) symptoms in subjects undergoing health checkups.
methodsWe utilized baseline data from 7,552 subjects who underwent upper endoscopy for health screening in a prospective, multicenter cohort study. The subjects were asked to complete a questionnaire detailing their upper abdominal symptoms and lifestyle. Based on the heartburn and/or acid regurgitation frequency, the EE subjects were stratified into the following three groups: (1) at least one day a week (symptomatic EE [sEE]), (2) less than one day a week (mild symptomatic EE [msEE]), and (3) never (asymptomatic EE [aEE]). Postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS) were defined according to the Rome III criteria.
resultsOf the 1,262 (16.7%) subjects (male 83.8%, mean age 52.6 years) with EE, the proportions of sEE, msEE and aEE were 15.0%, 37.2% and 47.9%, respectively. The sEE group showed significant associations with overlapping EPS (OR: 58.4, 95% CI: 25.2-160.0), overlapping PDS (OR: 9.96, 95% CI: 3.91-26.8), severe hiatal hernia (OR: 2.43, 95% CI: 1.43-4.05), experiencing high levels of stress (OR: 2.20, 95% CI: 1.43-3.40), atrophic gastritis (OR: 1.57, 95% CI: 1.03-2.36) and Los Angeles (LA) grade B or worse (OR: 1.72, 95% CI: 1.12-2.60) in the multivariate analysis.
conclusionsApproximately one-sixth of EE subjects were symptomatic. A multifactorial etiology, including factors unrelated to gastric acid secretion, was associated with the symptom presentation of EE subjects.
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