ArticlePloS one2018
Oral administration of short chain fatty acids could attenuate fat deposition of pigs.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Effects of Application of Lactobacilli on Lipid Metabolism in Monogastric and Aquatic Animals: Benefits and Underlying Mechanism.Animals : an open access journal from MDPI · 2026Review
- Sodium butyrate improved intestinal function in normal and glyphosate-challenged Nile tilapia (Oreochromis niloticus L.).Fish physiology and biochemistry · 2026Article
- Effect of the Interaction Between Dietary Fiber Structure and Apparent Viscosity on the Production Performance of Growing Pigs.Animals : an open access journal from MDPI · 2025Article
- Gut microbiota and metabolites in lipid metabolism and intramuscular fat deposition: mechanisms and implications for meat quality.Journal of animal science and biotechnology · 2025Review
- Investigation into Critical Gut Microbes Influencing Intramuscular Fat Deposition in Min Pigs.Animals : an open access journal from MDPI · 2024Article
- Harnessing Prebiotics to Improve Type 2 Diabetes Outcomes.Nutrients · 2024Review
- Review
- The Effect of Prebiotic Supplements on the Gastrointestinal Microbiota and Associated Health Parameters in Pigs.Animals : an open access journal from MDPI · 2023Review
- The Effect of Maternal Probiotic or Synbiotic Supplementation on Sow and Offspring Gastrointestinal Microbiota, Health, and Performance.Animals : an open access journal from MDPI · 2023Review
- Article
- Effects of sodium butyrate on growth performance, antioxidant status, inflammatory response and resistance to hypoxic stress in juvenile largemouth bass (Frontiers in immunology · 2023Article
- Breeding potential for pork belly to the novel economic trait.Journal of animal science and technology · 2023Review
- Gut Microbiome and Its Cofactors Are Linked to Lipoprotein Distribution Profiles.Microorganisms · 2022Article
- Influence of the Gut Microbiome on Feed Intake of Farm Animals.Microorganisms · 2022Review
- The Role of Gut Microbiota in the Skeletal Muscle Development and Fat Deposition in Pigs.Antibiotics (Basel, Switzerland) · 2022Article
- Effects of Low or High Dosages of Dietary Sodium Butyrate on the Growth and Health of the Liver and Intestine of Largemouth Bass,Aquaculture nutrition · 2022Article
- Resistant starch: Implications of dietary inclusion on gut health and growth in pigs: a review.Journal of animal science and biotechnology · 2021Review
- Short-chain fatty acids can improve lipid and glucose metabolism independently of the pig gut microbiota.Journal of animal science and biotechnology · 2021Article
- Modulation of Short-Chain Fatty Acids as Potential Therapy Method for Type 2 Diabetes Mellitus.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2021Review
- The Role of Short-Chain Fatty Acids of Gut Microbiota Origin in Hypertension.Frontiers in microbiology · 2021Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Short chain fatty acids (SCFAs) are the main products of indigestible carbohydrates that are fermented by microbiota in the hindgut. This study was designed to investigate the effects of oral SCFAs administration on the lipid metabolism of weaned pigs. A total of 21 barrows were randomly allocated into three groups, including control group (orally infused with 200 mL physiological saline per day), low dose SCFAs group (orally infused with 200 mL SCFAs containing acetic acid 20.04 mM, propionic acid 7.71 mM and butyric acid 4.89 mM per day), and high dose SCFAs group (orally infused with 200 mL SCFAs containing acetic acid 40.08 mM, propionic acid 15.42 mM and butyric acid 9.78 mM per day). The results showed that the average daily feed intake of SCFAs groups were lower than that of control group (P<0.05). Oral administration of SCFAs decreased the concentrations of triglyceride (TG), total cholesterol (TC), high density lipoprotein-cholesterol and insulin (P<0.05), and increased the leptin concentration in serum (P<0.05). The total fat, as well as TC and TG levels in liver, was decreased by oral SCFAs administration (P<0.05). In addition, SCFAs down-regulated the mRNA expressions of fatty acid synthase (FAS) and sterol regulatory element binding protein 1c (P<0.05), and enhanced the mRNA expression of carnitine palmitoyltransferase-1α (CPT-1α) in liver (P<0.05). SCFAs also decreased FAS, acetyl-CoA carboxylase (ACC) and peroxisome proliferator activated receptor σ mRNA expressions in longissimus dorsi (P<0.05). And in abdominal fat, SCFAs reduced FAS and ACC mRNA expressions (P<0.05), and increased CPT-1α mRNA expression (P<0.05). These results suggested that oral administration of SCFAs could attenuate fat deposition in weaned pigs via reducing lipogenesis and enhancing lipolysis of different tissues.
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Registered trials
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