ArticlePloS one2018
Micro/nano hierarchical structured titanium treated by NH4OH/H2O2 for enhancing cell response.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- In-vivo and ex-vivo evaluation of bio-inspired structures fabricated via PBF-LB for biomedical applications.Materials today. Bio · 2025Article
- Nanoscale Modification of Titanium Implants Improves Behaviors of Bone Mesenchymal Stem Cells and OsteogenesisOxidative medicine and cellular longevity · 2022Article
- Surface Modification of Additively Manufactured Nitinol by Wet Chemical Etching.Materials (Basel, Switzerland) · 2021Article
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Authors and funding
11 authors.
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Abstract
In this paper, two kinds of titanium surfaces with novel micro/nano hierarchical structures, namely Etched (E) surface and Sandblast and etched (SE) surface, were successfully fabricated by NH4OH and H2O2 mixture. And their cellular responses of MG63 were investigated compared with Sandblast and acid-etching (SLA) surface. Scanning electron microscope (SEM), Surface profiler, X-ray photoelectron spectroscopy (XPS), and Contact angle instrument were employed to assess the surface morphologies, roughness, chemistry and wettability respectively. Hierarchical structures with micro holes of 10-30 μm in diameter and nano pits of tens of nanometers in diameter formed on both E and SE surfaces. The size of micro holes is very close to osteoblast cell, which makes them wonderful beds for osteoblast. Moreover, these two kinds of surfaces possess similar roughness and superior hydrophilicity to SLA. Reactive oxygen species were detected on E and SE surface, and thus considerable antimicrobial performance and well fixation can be speculated on them. The cell experiments also demonstrated a boost in cell attachment, and that proliferation and osteogenic differentiation were achieved on them, especially on SE surface. The results indicate that the treatment of pure titanium with H2O2/NH4OH is an effective technique to improve the initial stability of implants and enhance the osseointegration, which may be a promising surface treatment to titanium implant.
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