Evidence map›Paper›PMID 29723209›Full record

ArticlePloS one2018

Cognitive dysfunction improves in systemic lupus erythematosus: Results of a 10 years prospective study.

Fulvia Ceccarelli, Carlo Perricone, Carmelo Pirone, Laura Massaro, Cristiano Alessandri, Concetta Mina, Massimo Marianetti, Francesca Romana Spinelli, Guido Valesini, Fabrizio Conti

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 62 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Fulvia CeccarelliLupus Clinic, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza University of Rome, Viale del Policlinico, Rome, Italy.ORCID 0000-0001-5026-8783
Carlo PerriconeLupus Clinic, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza University of Rome, Viale del Policlinico, Rome, Italy.
Carmelo PironeLupus Clinic, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza University of Rome, Viale del Policlinico, Rome, Italy.
Laura MassaroLupus Clinic, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza University of Rome, Viale del Policlinico, Rome, Italy.
Cristiano AlessandriLupus Clinic, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza University of Rome, Viale del Policlinico, Rome, Italy.
Concetta MinaDipartimento di Neurologia e ORL, Sapienza Università di Roma, Rome, Italy.
Massimo MarianettiDipartimento di Neurologia e ORL, Sapienza Università di Roma, Rome, Italy.
Francesca Romana SpinelliLupus Clinic, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza University of Rome, Viale del Policlinico, Rome, Italy.
Guido ValesiniLupus Clinic, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza University of Rome, Viale del Policlinico, Rome, Italy.
Fabrizio ContiLupus Clinic, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza University of Rome, Viale del Policlinico, Rome, Italy.
Policlinico Umberto I · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveCognitive impairment (CI) has been described in 3-80% of Systemic lupus erythematosus (SLE) patients but only short-term studies evaluated its over-time changes, suggesting that CI is usually a stable finding. We aimed at evaluating the changes of SLE-related CI in a 10-years prospective single center cohort study.

methodsWe evaluated 43 patients (M/F 5/38; mean age = 45.7±10.1 years; mean disease duration = 230.8±74.3 months) at baseline (T0) and after 10 years (T1). A test battery designed to detect fronto-subcortical dysfunction across five domains (memory, attention, abstract reasoning, executive and visuospatial function) was administered. A global cognitive dysfunction score (GCD) was obtained and associated with clinical and laboratory features.

resultsPrevalence of CI was 20.9% at T0 and 13.9% at T1 (P = NS). This impairment was prevalently mild at T0 (55.5%) and mild or moderate at T1 (36.3% for both degrees). After 10 years, CI improved in 50% of patients, while 10% worsened. Impaired memory (P = 0.02), executive functions (P = 0.02) and abstract reasoning (P = 0.03) were associated with dyslipidemia at T0. Worsening of visuospatial functions was significantly associated with dyslipidemia and Lupus Anticoagulant (P = 0.04 for both parameters). Finally, GCD significantly correlated with chronic damage measured by SLICC/damage index at T0 (r = 0.3; P = 0.04) and T1 (r = 0.3; P = 0.03).

conclusionsFor the first time, we assessed CI changes over 10-years in SLE. CI improved in the majority of the patients. Furthermore, we observed an improvement of the overall cognitive functions. These results could suggest that an appropriate management of the disease during the follow-up could be able to control SLE-related CI.

Indexed as

AttentionCognitive DysfunctionExecutive FunctionFemaleHumansLupus Erythematosus, SystemicMaleMemoryMiddle AgedProspective Studies

Identifiers

PMID29723209
PMCPMC5933733
OpenAlexW2801606942

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.