ArticleAging2018
CircRNAs in the tree shrew (
Article in Aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Article
- Cross-Species Insights from Single-Nucleus Sequencing Highlight Aging-Related Hippocampal Features in Tree Shrew.Molecular biology and evolution · 2025Article
- Cellular Characterization and Interspecies Evolution of the Tree Shrew Retina across Postnatal Lifespan.Research (Washington, D.C.) · 2024Article
- Biological functions of circRNAs and their advance on skeletal muscle development in bovine.3 Biotech · 2023Review
- Circular RNA Involvement in Aging and Longevity.Current genomics · 2022Review
- An analysis of neurovascular disease markers in the hippocampus ofFrontiers in neurology · 2022Article
- Role of circRNAs in neurodevelopment and neurodegenerative diseases.Journal of molecular neuroscience : MN · 2021Review
- Canonical and Interior Circular RNAs Function as Competing Endogenous RNAs in Psoriatic Skin.International journal of molecular sciences · 2021Article
- Expression and function of circular RNAs in the mammalian brain.Cellular and molecular life sciences : CMLS · 2021Review
- Comparing the hippocampal miRNA expression profiles of wild and domesticated Chinese tree shrews (Tupaia belangeri chinensis).BMC ecology and evolution · 2021Article
- A Narrative Review of Circular RNAs in Brain Development and Diseases of Preterm Infants.Frontiers in pediatrics · 2021Review
- Transposable elements, circular RNAs and mitochondrial transcription in age-related genomic regulation.Development (Cambridge, England) · 2020Review
- The Circular RNome of Developmental Retina in Mice.Molecular therapy. Nucleic acids · 2020Article
- Disease-Associated Circular RNAs: From Biology to Computational Identification.BioMed research international · 2020Review
- Comparative genomic analysis of Proteus spp. isolated from tree shrews indicated unexpectedly high genetic diversity.PloS one · 2020Article
- Interior circular RNA.RNA biology · 2020Article
- Identification of CircRNA-miRNA-mRNA Regulatory Network in Gastrointestinal Stromal Tumor.Frontiers in genetics · 2020Article
- The characteristics of gut microbiota and commensal Enterobacteriaceae isolates in tree shrew (Tupaia belangeri).BMC microbiology · 2019Article
- Circular RNA profile in liver tissue of EpCAM knockout mice.International journal of molecular medicine · 2019Article
- Altered expression of circular RNAs in human placental chorionic plate-derived mesenchymal stem cells pretreated with hypoxia.Journal of clinical laboratory analysis · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circular RNAs (circRNAs) are a novel type of non-coding RNA expressed across different species and tissues. At present, little is known about the expression and function of circRNAs in the tree shrew brain. In this study, we used RNA-seq to identify 35,007 circRNAs in hippocampus and cerebellum samples from infant (aged 47-52 days), young (aged 15-18 months), and old (aged 78-86 months) tree shrews. We observed no significant changes in the total circRNA expression profiles in different brain regions over time. However, circRNA tended to be downregulated in the cerebellum over time. Real-time RT-PCR analysis verified the presence of circRNAs. KEGG analysis indicated the occurrence of ubiquitin-mediated proteolysis, the MAPK signaling pathway, phosphatidylinositol signaling system, long-term depression, the rap1 signaling pathway, and long-term potentiation in both brain regions. We also observed that 29,087 (83.1%) tree shrew circRNAs shared homology with human circRNAs. The competing endogenous RNA networks suggested novel_circRNA_007362 potential functions as a 24-miRNAs sponge to regulate UBE4B expression. Thus, we obtained comprehensive circRNA expression profiles in the tree shrew brain during postnatal development and aging, which might help to elucidate the functions of circRNAs during brain aging and in age-related diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.