Evidence map›Paper›PMID 29723105›Full record

Trial reportGut microbes2018

Probiotics drive gut microbiome triggering emotional brain signatures.

Deepika Bagga, Johanna Louise Reichert, Karl Koschutnig, Christoph Stefan Aigner, Peter Holzer, Kaisa Koskinen, Christine Moissl-Eichinger, Veronika Schöpf

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Gut microbes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 7 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 7 syntheses or guidelines pooled it, 232 citations in OpenAlex.

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58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Deepika Baggaa Department of Neuroimaging, Institute of Psychology , University of Graz , Graz , Austria.ORCID 0000-0003-3079-457X
Johanna Louise Reicherta Department of Neuroimaging, Institute of Psychology , University of Graz , Graz , Austria.ORCID 0000-0002-8955-3271
Karl Koschutniga Department of Neuroimaging, Institute of Psychology , University of Graz , Graz , Austria.ORCID 0000-0001-6234-0498
Christoph Stefan Aignerc Department of Computer Science and Biomedical Engineering , Institute of Medical Engineering, Graz University of Technology , Graz , Austria.ORCID 0000-0003-3618-9610
Peter Holzerb BioTechMed , Graz , Austria.ORCID 0000-0002-5754-395X
Kaisa Koskinenb BioTechMed , Graz , Austria.ORCID 0000-0001-5727-8415
Christine Moissl-Eichingerb BioTechMed , Graz , Austria.ORCID 0000-0001-6755-6263
Veronika Schöpfa Department of Neuroimaging, Institute of Psychology , University of Graz , Graz , Austria.ORCID 0000-0003-1937-4216
University of Graz · ATMedical University of Graz · ATGraz University of Technology · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Experimental manipulation of the gut microbiome was found to modify emotional and cognitive behavior, neurotransmitter expression and brain function in rodents, but corresponding human data remain scarce. The present double-blind, placebo-controlled randomised study aimed at investigating the effects of 4 weeks' probiotic administration on behavior, brain function and gut microbial composition in healthy volunteers. Forty-five healthy participants divided equally into three groups (probiotic, placebo and no intervention) underwent functional MRI (emotional decision-making and emotional recognition memory tasks). In addition, stool samples were collected to investigate the gut microbial composition. Probiotic administration for 4 weeks was associated with changes in brain activation patterns in response to emotional memory and emotional decision-making tasks, which were also accompanied by subtle shifts in gut microbiome profile. Microbiome composition mirrored self-reported behavioral measures and memory performance. This is the first study reporting a distinct influence of probiotic administration at behavioral, neural, and microbiome levels at the same time in healthy volunteers. The findings provide a basis for future investigations into the role of the gut microbiota and potential therapeutic application of probiotics.

Indexed as

Bacterial Physiological PhenomenaEmotionsProbioticsAdultBacteriaBrainDecision MakingDouble-Blind MethodFecesFemaleGastrointestinal MicrobiomeHealthy VolunteersHumansMagnetic Resonance ImagingMalePlacebosPlacebosRNA, Ribosomal, 16SbehaviorEmotional decisionfMRImicrobiomeprobioticsrecognition, memorystool

Identifiers

PMID29723105
PMCPMC6287679
OpenAlexW2802886512

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.