Evidence map›Paper›PMID 29722648›Full record

ArticleeLife2018

Distinct 'safe zones' at the nuclear envelope ensure robust replication of heterochromatic chromosome regions.

Hani Ebrahimi, Hirohisa Masuda, Devanshi Jain, Julia Promisel Cooper

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 37 citations in OpenAlex.

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  14. Integrity of a heterochromatic domain ensured by its boundary elements.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Hani Ebrahimi *Telomere Biology Section, Laboratory of Biochemistry and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, United States.
Hirohisa Masuda *Telomere Biology Section, Laboratory of Biochemistry and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, United States.
Devanshi JainTelomere Biology Section, Laboratory of Biochemistry and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, United States.
Julia Promisel CooperTelomere Biology Section, Laboratory of Biochemistry and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, United States.ORCID 0000-0003-2171-2587
National Cancer Institute · US

Funding

Telomere BiologyZIABC011519 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI COOPER, JULIA · 2013 to 2020
$13.1M
NCI NIH HHS Intramural funding
6 · The paper itself

Abstract

Chromosome replication and transcription occur within a complex nuclear milieu whose functional subdomains are beginning to be mapped out. Here we delineate distinct domains of the fission yeast nuclear envelope (NE), focusing on regions enriched for the inner NE protein, Bqt4, or the lamin interacting domain protein, Lem2. Bqt4 is relatively mobile around the NE and acts in two capacities. First, Bqt4 tethers chromosome termini and the

Indexed as

Chromosomes, FungalDNA ReplicationTranscription, GeneticDNA-Binding ProteinsHeterochromatinMembrane ProteinsModels, BiologicalNuclear EnvelopeNuclear ProteinsSchizosaccharomycesSchizosaccharomyces pombe ProteinsBqt4 protein, S pombeDNA-Binding ProteinsHeterochromatinLem2 protein, S pombeMembrane ProteinsNuclear ProteinsSchizosaccharomyces pombe Proteinscell biologychromosomesgene expressiongenes and chromosomesS. pombe

Identifiers

PMID29722648
PMCPMC5933923
OpenAlexW2765368979

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.