Evidence map›Paper›PMID 29722481›Full record

Trial reportPediatric blood & cancer2018

Randomized web-based physical activity intervention in adolescent survivors of childhood cancer.

Carrie R Howell, Kevin R Krull, Robyn E Partin, Nina S Kadan-Lottick, Leslie L Robison, Melissa M Hudson, Kirsten K Ness

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pediatric blood & cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07522905 (The Impact of a 12-week Virtual Buddy-movement Therapy on the Psychomotor and Social Development of Pediatric Oncology Patients in Remission), which is not on this map. Cited by 42 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 12 pooled it
10.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07522905 narecruitingnot on this mapstarted 2026, after this paper: background citation

The Impact of a 12-week Virtual Buddy-movement Therapy on the Psychomotor and Social Development of Pediatric Oncology Patients in Remission

TypeinterventionalSponsorComenius UniversityRan2026 to 2027Enrolled24ConditionsPrecursor Cell Lymphoblastic Leukemia-LymphomaArmsVirtual BUDDY-Movement Therapy
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 12 syntheses or guidelines pooled it, 83 citations in OpenAlex.

  1. Psychosocial interventions for children and adolescents across the cancer care continuum: A systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  17. Childhood cancer and future cardiometabolic health.npj metabolic health and disease · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Carrie R HowellDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0002-6554-6237
Kevin R KrullDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.
Robyn E PartinDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.
Nina S Kadan-LottickYale School of Medicine, Yale University, New Haven, Connecticut.ORCID 0000-0002-6857-396X
Leslie L RobisonDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.
Melissa M HudsonDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.
Kirsten K NessDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.
St. Jude Children's Research Hospital · USYale University · US

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
NCI NIH HHS P30 CA021765
6 · The paper itself

Abstract

backgroundHealthy lifestyle choices, including participation in regular physical activity, may improve health outcomes in survivors of childhood cancer. We aimed to evaluate the efficacy of a web-delivered physical activity intervention among adolescent survivors to increase moderate to vigorous physical activity (MVPA) and improve fitness and neurocognitive and health-related quality of life (HRQoL) over 24 weeks. PROCEDURE: This randomized controlled trial was conducted among survivors (aged ≥11 to <15 years) treated at a single institution. Participants were randomized to either a physical activity intervention delivered over the internet or a control group. The intervention group received educational materials, an activity monitor, and access to an interactive website designed to motivate increased physical activity via rewards; the control group received an activity monitor and educational materials. Physical activity, fitness, and neurocognitive and HRQoL outcomes were assessed at baseline and at 24 weeks. Mean changes were compared between groups using paired t-tests.

resultsOf the 97 survivors enrolled, 78 completed the study; the mean age was 12.7 (standard deviation 1.1), 80% were White, and 55.1% were female. Fifty-three survivors were assigned to the intervention and 25 to the control group. While survivors in the intervention group increased, and those in the control group decreased (4.7 ± 119.9 vs. -24.3 ± 89.7 min) weekly MVPA, this difference was not significant (P = 0.30). However, hand grip strength, number of sit-ups and pushups, neurocognitive function, and HRQoL outcomes improved in the intervention, but not in the control group.

conclusionsAn interactive, rewards-based intervention designed to increase MVPA is feasible in adolescent survivors of childhood cancer.

Indexed as

Cancer SurvivorsExercise TherapyInternetAdolescentChildCognitionFemaleHand StrengthHumansMaleNeoplasmsPatient Education as TopicQuality of Lifehealth-related quality of lifepediatric cancer survivorphysical activityweb-based intervention

Identifiers

PMID29722481
PMCPMC6019155
OpenAlexW2802571687

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.