ArticlePaediatric anaesthesia2018
Estimating pediatric general anesthesia exposure: Quantifying duration and risk.
Article in Paediatric anaesthesia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Preoperative Virtual Reality for Pediatric Patients Undergoing General Anesthesia: A Meta-Analysis of Randomized Controlled Trial.Paediatric anaesthesia · 2025Pooled it
- Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial.Lancet (London, England) · 2019Trial
- Virtual Reality for Pain Management During Repeated Pediatric Laser Procedures: Protocol for a Pilot Randomized Clinical Trial.JMIR research protocols · 2026Article
- Article
- Reimagining Pediatric Dental Behavior Guidance: Introducing the Strategic Structured Collaborative Technique.International journal of clinical pediatric dentistry · 2025Article
- Perioperative Anaesthetic Approaches to Paediatric Patients: A National Survey.Turkish journal of anaesthesiology and reanimation · 2025Article
- Perioperative Complications in Children with Down Syndrome: A Single Center Retrospective Analysis-Original Clinical Research Report.Journal of clinical medicine · 2025Article
- Comparing Management Strategies for Thoracolumbar Injury Classification and Severity Score of 4 (TLICS = 4) in the Pediatric Population: A Single-Institutional Experience.Children (Basel, Switzerland) · 2024Article
- A pragmatic methodology to extract anesthetic and physiological data from the electronic health record.Paediatric anaesthesia · 2024Article
- The residency levels' effect on pediatric dental rehabilitation operation time.BMC medical education · 2024Article
- Neurobehavioral effects of general anesthesia and cochlear implantation on hearing-impaired infants: A prospective observational cohort study.Brain and behavior · 2023Observational
- Effects of anesthesia exposure on postnatal maturation of white matter in rhesus monkeys.Developmental psychobiology · 2023Article
- Pediatric Elbow Dislocations and Associated Fractures.Children (Basel, Switzerland) · 2023Article
- Neonatal exposure to a neuroactive steroid alters low-frequency oscillations in the subiculum.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Controversies in anesthesia-induced developmental neurotoxicity.Best practice & research. Clinical anaesthesiology · 2023Review
- Comparison of parental and practitioner's acceptance for dental treatment under general anaesthesia in paediatric patients.BMC pediatrics · 2023Article
- Ophthalmology examinations under anaesthesia carried out on non-ophthalmology lists in a specialist children's hospital.Eye (London, England) · 2022Article
- General anaesthesia during infancy reduces white matter micro-organisation in developing rhesus monkeys.British journal of anaesthesia · 2021Article
- [Effect of Long-time Postnatal Exposure to Sevoflurane on Causing Attention-deficit/Hyperactivity Disorder in Rats].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2021Article
- Audiological and otologic manifestations of glutaric aciduria type I.Orphanet journal of rare diseases · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
introductionUnderstanding the duration of pediatric general anesthesia exposure in contemporary practice is important for identifying groups at risk for long general anesthesia exposures and designing trials examining associations between general anesthesia exposure and neurodevelopmental outcomes.
methodsWe performed a retrospective cohort analysis to estimate pediatric general anesthesia exposure duration during 2010-2015 using the National Anesthesia Clinical Outcomes Registry.
resultsA total of 1 548 021 pediatric general anesthetics were included. Median general anesthesia duration was 57 minutes (IQR: 28-86) with 90th percentile 145 minutes. Children aged <1 year had the longest median exposure duration (79 minutes, IQR: 39-119) with 90th percentile 210 minutes, and 13.7% of this very young cohort was exposed for >3 hours. High ASA physical status and care at a university hospital were associated with longer exposure times.
conclusionWhile the vast majority (94%) of children undergoing general anesthesia are exposed for <3 hours, certain groups may be at increased risk for longer exposures. These findings may help guide the design of future trials aimed at understanding neurodevelopmental impact of prolonged exposure in these high-risk groups.
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Registered trials
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