ArticleHuman brain mapping2018
Deficient supplementary motor area at rest: Neural basis of limb kinetic deficits in Parkinson's disease.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Altered regional spontaneous brain activity in Parkinson's disease: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Cortical Activation During Finger Tapping Task Performance in Parkinson's Disease Is Influenced by Priming Conditions: An ALE Meta-Analysis.Frontiers in human neuroscience · 2021Pooled it
- White Matter Abnormalities in Patients With Parkinson's Disease: A Meta-Analysis of Diffusion Tensor Imaging Using Tract-Based Spatial Statistics.Frontiers in aging neuroscience · 2020Pooled it
- The effects of task-specific home-based touchscreen training in people with Parkinson's disease: a pilot randomized controlled trial.Journal of neurology · 2025Trial
- Effects of anodal stimulation and motor practice on limb-kinetic apraxia in Parkinson's disease.Experimental brain research · 2022Trial
- Assessing Limb Apraxia in Quebec: Normative Study of the Brief Battery for the Evaluation of Praxis in Healthy French-Speaking Adults.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026Article
- Limb-Kinetic apraxia of legs in Parkinson's disease: Prospective clinical investigation.Clinical parkinsonism & related disorders · 2025Article
- Feasibility of a combined intermittent theta-burst stimulation and video game-based dexterity training in Parkinson's disease.Journal of neuroengineering and rehabilitation · 2023Article
- Role of Diffusion Tensor Tractography in Diagnosis of Limb-Kinetic Apraxia in Stroke Patients: A Mini-Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2022Review
- Aberrant cerebral perfusion pattern in amnestic mild cognitive impairment and Parkinson's disease with mild cognitive impairment: a comparative arterial spin labeling study.Quantitative imaging in medicine and surgery · 2021Article
- Motor asymmetry related cerebral perfusion patterns in Parkinson's disease: An arterial spin labeling study.Human brain mapping · 2021Article
- Altered Regional Homogeneity and Functional Connectivity during Microlesion Period after Deep Brain Stimulation in Parkinson's Disease.Parkinson's disease · 2021Article
- Combining Repetitive Transcranial Magnetic Stimulation and Video Game-Based Training to Improve Dexterity in Parkinson's Disease: Study Protocol of a Randomized Controlled Trial.Frontiers in rehabilitation sciences · 2021Article
- A Neural Signature of Parkinsonism in Patients With Schizophrenia Spectrum Disorders: A Multimodal MRI Study Using Parallel ICA.Schizophrenia bulletin · 2020Article
- Disrupted Regional Cerebral Blood Flow in Children With Newly-Diagnosed Type 1 Diabetes Mellitus: An Arterial Spin Labeling Perfusion Magnetic Resonance Imaging Study.Frontiers in neurology · 2020Article
- Dopaminergic modulation of the praxis network in Parkinson's disease.NeuroImage. Clinical · 2019Article
- Deficient supplementary motor area at rest: Neural basis of limb kinetic deficits in Parkinson's disease.Human brain mapping · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinson's disease (PD) patients frequently suffer from limb kinetic apraxia (LKA) affecting quality of life. LKA denotes an impairment of precise and independent finger movements beyond bradykinesia, which is reliably assessed by coin rotation (CR) task. BOLD fMRI detected activation of a left inferior parietal-premotor praxis network in PD during CR. Here, we explored which network site is most critical for LKA using arterial spin labeling (ASL). Based on a hierarchical model, we hypothesized that LKA would predominantly affect the functional integrity of premotor areas including supplementary motor areas (SMA). Furthermore, we suspected that for praxis function with higher demand on temporal-spatial processing such as gesturing, inferior parietal lobule (IPL) upstream to premotor areas would be essential. A total of 21 PD patients and 20 healthy controls underwent ASL acquisition during rest. Behavioral assessment outside the scanner involved the CR, finger tapping task, and the test of upper limb apraxia (TULIA). Whole-brain analysis of activity at rest showed a significant reduction of CR-related perfusion in the left SMA of PD. Furthermore, the positive correlation between SMA perfusion and CR, seen in controls, was lost in patients. By contrast, TULIA was significantly associated with the perfusion of left IPL in both patients and controls. In conclusion, the findings suggest that LKA in PD are linked to an intrinsic disruption of the left SMA function, which may only be overcome by compensatory network activation. In addition, gestural performance relies on IPL which remains available for functional recruitment in early PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.