Evidence map›Paper›PMID 29721966›Full record

ArticleAdvances in experimental medicine and biology2018

Impact of MCT1 Haploinsufficiency on the Mouse Retina.

Neal S Peachey, Minzhong Yu, John Y S Han, Sylvain Lengacher, Pierre J Magistretti, Luc Pellerin, Nancy J Philp

Abstract read
In one paragraph

Article in Advances in experimental medicine and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Role of monocarboxylate transporters in regulating metabolic homeostasis in the outer retina: Insight gained from cell-specific Bsg deletion.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Neal S PeacheyLouis Stokes Cleveland VA Medical Center, Cleveland, OH, USA. neal.peachey@va.gov.
Minzhong YuCole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.
John Y S HanDepartment of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Sylvain LengacherBrain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Pierre J MagistrettiBrain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Luc PellerinDepartment of Physiology, University of Lausanne, Lausanne, Switzerland.
Nancy J PhilpDepartment of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.

Funding

Alcohol Tissue InjuryT32AA007463 · NIAAA · THOMAS JEFFERSON UNIVERSITY · PI HOEK, JOANNES B, VADIGEPALLI, RAJANIKANTH · 1985 to 2021
$9.1M
RPE LACTATE TRANSPORTERS--A ROLE IN RETINAL SURVIVALR01EY012042 · NEI · THOMAS JEFFERSON UNIVERSITY · PI PHILP, NANCY JEAN · 1998 to 2018
$5.7M
BESTROPHIN AND RETINAL DISEASER01EY013160 · NEI · UNIVERSITY OF ARIZONA · PI MARMORSTEIN, ALAN D · 2000 to 2013
$5.0M
Metabolism of Lactate in the Outer RetinaI01BX002340 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI PEACHEY, NEAL S. · 2014 to 2016
–
BLRD VA I01 BX002340BLRD VA IK6 BX005233NEI NIH HHS R01 EY012042NEI NIH HHS R01 EY013160NEI NIH HHS R01EY2042NIAAA NIH HHS T32 AA007463
6 · The paper itself

Abstract

The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1

Indexed as

AnimalsElectroretinographyEnergy MetabolismEvoked Potentials, VisualHeterozygoteLactatesMiceMice, Inbred C57BLMice, TransgenicMonocarboxylate Transport Protein 1Monocarboxylic Acid TransportersMotor NeuronsOligodendrogliaPhotoreceptor Cells, VertebrateRetinaRetinal Bipolar CellsLactatesMonocarboxylate Transport Protein 1Monocarboxylic Acid TransportersSymportersElectroretinogramLactateMCT1RetinaTransgenic mice

Identifiers

PMID29721966
PMCPMC6708593

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.