Evidence map›Paper›PMID 29721764›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2020

18-FDG-PET in a patient cohort suspected for cardiac sarcoidosis: Right ventricular uptake is associated with pathological uptake in mediastinal lymph nodes.

Heikki Tuominen, Atte Haarala, Antti Tikkakoski, Mika Kähönen, Kjell Nikus, Kalle Sipilä

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Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. FDG uptake patterns in isolated and systemic cardiac sarcoidosis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  3. Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2020: positron emission tomography, computed tomography, and magnetic resonance.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Review
  4. Article
  5. Article
  6. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Observational
  7. Importance of extracardiac FDG uptake to diagnose cardiac sarcoidosis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Heikki TuominenDepartment of Clinical Physiology and Nuclear Medicine, Tampere University Hospital, Teiskontie 35, 33520, Tampere, Finland. heikki.p.tuominen@gmail.com.
Atte HaaralaDepartment of Clinical Physiology and Nuclear Medicine, Tampere University Hospital, Teiskontie 35, 33520, Tampere, Finland.
Antti TikkakoskiDepartment of Clinical Physiology and Nuclear Medicine, Tampere University Hospital, Teiskontie 35, 33520, Tampere, Finland.
Mika KähönenDepartment of Clinical Physiology and Nuclear Medicine, Tampere University Hospital, Teiskontie 35, 33520, Tampere, Finland.
Kjell NikusFaculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Kalle SipiläDepartment of Clinical Physiology and Nuclear Medicine, Tampere University Hospital, Teiskontie 35, 33520, Tampere, Finland.
Tampere University · FITampere University · FITampere University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn up to 65% of cardiac sarcoidosis patients, the disease is confined to the heart. Diagnosing isolated cardiac sarcoidosis is challenging due to the low sensitivity of endomyocardial biopsy. If cardiac sarcoidosis is part of biopsy-confirmed systemic sarcoidosis, the diagnosis can be based on cardiac imaging studies. We compared the imaging features of patients with isolated cardiac FDG uptake on positron emission tomography with those who had findings indicative of systemic sarcoidosis. MATERIALS AND

methods137 consecutive cardiac FDG-PET/CT studies performed on subjects suspected of having cardiac sarcoidosis were retrospectively analyzed.

results33 patients had pathological left ventricular FDG uptake, and 12 of these also had pathological right ventricular uptake. 16/33 patients with pathological cardiac uptake had pathological extracardiac uptake. 10/12 patients with both LV- and RV-uptake patterns had extracardiac uptake compared to 6/21 of those with pathological LV uptake without RV uptake. SUVmax values in the myocardium were higher among patients with abnormal extracardiac uptake. The presence of extracardiac uptake was the only imaging-related factor that could predict a biopsy indicative of sarcoidosis.

conclusionRight ventricular involvement seems to be more common in patients who also have findings suggestive of suspected systemic sarcoidosis, compared with patients with PET findings indicative of isolated cardiac disease.

Indexed as

AdultAgedCardiomyopathiesCohort StudiesFemaleFluorodeoxyglucose F18Heart VentriclesHumansLymph NodesMaleMediastinumMiddle AgedPositron Emission Tomography Computed TomographyRadiopharmaceuticalsSarcoidosisFluorodeoxyglucose F18RadiopharmaceuticalsDiagnostic and prognostic applicationInflammationPET

Identifiers

PMID29721764
OpenAlexW2801370768

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.