ReviewEuropean journal of nuclear medicine and molecular imaging2018
Automated assessment of FDG-PET for differential diagnosis in patients with neurodegenerative disorders.
Review in European journal of nuclear medicine and molecular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Diagnostic performance of molecular imaging methods in predicting the progression from mild cognitive impairment to dementia: an updated systematic review.European journal of nuclear medicine and molecular imaging · 2024Pooled it
- Correspondence of Basal Forebrain Resting-State Functional Connectivity and Cerebral Glucose Metabolism Alterations With Neurotransmitter Maps in Alzheimer's Disease.CNS neuroscience & therapeutics · 2026Article
- Metabolic brain networks in dementia with Lewy bodies: from prodromal to manifest disease stages.Journal of neurology, neurosurgery, and psychiatry · 2026Article
- Cerebrospinal fluid NPTX2 and [Alzheimer's research & therapy · 2025Article
- The basics of PET molecular imaging in neurodegenerative disorders with dementia and/or parkinsonism.European radiology · 2025Review
- Data-Driven Image-Based Protocol for Brain PET Image Harmonization.Sensors (Basel, Switzerland) · 2025Article
- Brain health services for the secondary prevention of cognitive impairment and dementia: Opportunities, challenges, and the business case for existing and future facilities.The journal of prevention of Alzheimer's disease · 2025Review
- Factors associated with true-positive and false-positive diagnoses of behavioural variant frontotemporal dementia in 100 consecutive referrals from specialist physicians.European journal of neurology · 2025Article
- Quantifying metabolic decrement in brain FDG-PET of a complex frontotemporal dementia case.Dementia & neuropsychologia · 2025Article
- Observational
- A ROI-based quantitative pipeline forHeliyon · 2024Article
- Harmonization of brain PET images in multi-center PET studies using Hoffman phantom scan.EJNMMI physics · 2023Article
- Identification and validation of Alzheimer's disease-related metabolic brain pattern in biomarker confirmed Alzheimer's dementia patients.Scientific reports · 2022Article
- Added value of semiquantitative analysis of brain FDG-PET for the differentiation between MCI-Lewy bodies and MCI due to Alzheimer's disease.European journal of nuclear medicine and molecular imaging · 2022Article
- EANM procedure guidelines for brain PET imaging using [European journal of nuclear medicine and molecular imaging · 2022Article
- Automated differential diagnosis of dementia syndromes using FDG PET and machine learning.Frontiers in aging neuroscience · 2022Article
- Validation of FDG-PET datasets of normal controls for the extraction of SPM-based brain metabolism maps.European journal of nuclear medicine and molecular imaging · 2021Article
- SimPET-An open online platform for the Monte Carlo simulation of realistic brain PET data. Validation forMedical physics · 2021Article
- The pons as reference region for intensity normalization in semi-quantitative analysis of brainEJNMMI research · 2021Article
- Voxel-Based Analysis of [18F]-FDG Brain PET in Rats Using Data-Driven Normalization.Frontiers in medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 9 institutions in 9 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo review literature until November 2015 and reach a consensus on whether automatic semi-quantification of brain FDG-PET is useful in the clinical setting for neurodegenerative disorders.
methodsA literature search was conducted in Medline, Embase, and Google Scholar. Papers were selected with a lower limit of 30 patients (no limits with autopsy confirmation). Consensus recommendations were developed through a Delphi procedure, based on the expertise of panelists, who were also informed about the availability and quality of evidence, assessed by an independent methodology team.
resultsCritical outcomes were available in nine among the 17 papers initially selected. Only three papers performed a direct comparison between visual and automated assessment and quantified the incremental value provided by the latter. Sensitivity between visual and automatic analysis is similar but automatic assessment generally improves specificity and marginally accuracy. Also, automated assessment increases diagnostic confidence. As expected, performance of visual analysis is reported to depend on the expertise of readers.
conclusionsTools for semi-quantitative evaluation are recommended to assist the nuclear medicine physician in reporting brain FDG-PET pattern in neurodegenerative conditions. However, heterogeneity, complexity, and drawbacks of these tools should be known by users to avoid misinterpretation. Head-to-head comparisons and an effort to harmonize procedures are encouraged.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.