ArticleJournal of gastroenterology2018
Impact of tumor localization on the outcomes of surgery for an intrahepatic cholangiocarcinoma.
Article in Journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- An individualized nomogram for survival prediction in intrahepatic cholangiocarcinoma: a population-based analysis.World journal of surgical oncology · 2026Article
- Oncological Resectability Criteria for Intrahepatic Cholangiocarcinoma: A Preoperative Framework for Multidisciplinary Management.Annals of surgical oncology · 2025Article
- [Frozen sections in hepatobiliary surgery].Chirurgie (Heidelberg, Germany) · 2025Review
- Surgical interpretation of the WHO subclassification of intrahepatic cholangiocarcinoma: a narrative review.Surgery today · 2025Review
- Article
- Prognostic impact of lymph node dissection in intrahepatic cholangiocarcinoma: a propensity score analysis.Langenbeck's archives of surgery · 2024Article
- Diacylglycerol kinase alpha is a proliferation marker of intrahepatic cholangiocarcinoma associated with the prognosis.Cancer medicine · 2024Article
- Clinicopathological features of cholangiolocarcinoma and impact of tumor heterogeneity on prognosis: A single institution retrospective study.Oncology letters · 2024Article
- Prognostic impact of lung recurrence in patients with biliary tract cancer.Langenbeck's archives of surgery · 2023Article
- Clinical implications and optimal extent of lymphadenectomy for intrahepatic cholangiocarcinoma: A multicenter analysis of the therapeutic index.Annals of gastroenterological surgery · 2023Article
- Preoperative subcategorization based on magnetic resonance imaging in intrahepatic cholangiocarcinoma.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023Article
- The Impact of a Preoperative Staging System on Accurate Prediction of Prognosis in Intrahepatic Cholangiocarcinoma.Cancers · 2022Article
- Impact of lymph node dissection on clinical outcomes of intrahepatic cholangiocarcinoma: Inverse probability of treatment weighting with survival analysis.Journal of hepato-biliary-pancreatic sciences · 2022Article
- Tumor Burden Score Stratifies Prognosis of Patients With Intrahepatic Cholangiocarcinoma After Hepatic Resection: A Retrospective, Multi-Institutional Study.Frontiers in oncology · 2022Article
- Evaluation of nodal status in intrahepatic cholangiocarcinoma: a population-based study.Annals of translational medicine · 2021Article
- Investigation of a Tumor Location-Specific Therapeutic Strategy for Intrahepatic Cholangiocarcinoma.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Invasion category-oriented lymph node metastases of cholangiocarcinoma and the prognostic impact.Langenbeck's archives of surgery · 2020Article
- Intention-to-treat curative liver resection in patients with "very early" intrahepatic cholangiocarcinoma.Langenbeck's archives of surgery · 2020Article
- Prognostic impact of CD8+ T cell distribution and its association with the HLA class I expression in intrahepatic cholangiocarcinoma.Surgery today · 2020Article
- Effect of Tumor Size on Long-Term Survival After Resection for Solitary Intrahepatic Cholangiocarcinoma.Frontiers in oncology · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntrahepatic cholangiocarcinoma (ICC) shows differing clinical outcomes depending on its localization.
methodsWe reviewed the surgical outcomes of 104 ICC patients who underwent liver resection at our institution. We divided ICC into hilar type (HICC) and peripheral type (PICC) depending on positive contact with the hepatic hilum on preoperative computed tomography (CT).
resultsThe survival outcomes were significantly poorer in HICC patients. HICCs showed a larger tumor size and more frequent bile duct invasion, lymph node metastasis, and non-curative resection than PICC. Resections for HICC had greater blood loss and required a longer operation time, larger hepatectomy, and more frequent extrahepatic bile duct resection. HICCs, even if small in size, also showed a greater tendency to metastasize to the lymph nodes of the hepatoduodenal ligament. Univariate analysis of the ICCs in our current cohort revealed that tumor size, multiple tumors, bile duct invasion, lymph node metastasis, non-curative resection, and HICC are associated with a poorer overall survival outcome. Multivariate analysis indicated that multiple tumors and non-curative resection were independent prognostic factors for survival. Among the curative resection cases, however, survival did not differ significantly between HICC and PICC. The accuracy rate of our CT-based classification for the pathological classification was 81.7%.
conclusionsHICC shows more frequent bile duct invasion and lymph node metastasis, requires more extensive surgery, and has a higher rate of non-curative resection than PICC. However, if curative resection is achieved, the survival outcomes are expected to be equivalent between HICC and PICC.
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