Evidence map›Paper›PMID 29721609›Full record

ArticleVirchows Archiv : an international journal of pathology2018

MMP-7 expression may influence the rate of distant recurrences and disease-specific survival in HPV-positive oropharyngeal squamous cell carcinoma.

Seija I Vento, Lauri Jouhi, Hesham Mohamed, Caj Haglund, Antti A Mäkitie, Timo Atula, Jaana Hagström, Laura K Mäkinen

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Article in Virchows Archiv : an international journal of pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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5citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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5 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Seija I VentoDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, P.O. Box 263, 00029 HUS, Helsinki, Finland. seija.vento@hus.fi.
Lauri JouhiDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, P.O. Box 263, 00029 HUS, Helsinki, Finland.
Hesham MohamedDepartment of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Caj HaglundDepartment of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Antti A MäkitieDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, P.O. Box 263, 00029 HUS, Helsinki, Finland.
Timo AtulaDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, P.O. Box 263, 00029 HUS, Helsinki, Finland.
Jaana HagströmDepartment of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Laura K MäkinenDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, P.O. Box 263, 00029 HUS, Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to determine if matrix metalloproteinase-7 (MMP-7) expression is related to human papilloma virus (HPV) status, clinical parameters, and outcome in oropharyngeal squamous cell carcinoma (OPSCC). Tumor tissue specimens from 201 OPSCC patients treated with curative intent were available for immunohistochemistry, and the samples were stained with monoclonal MMP-7 antibody. All the patients were followed up at least 3 years or until death. MMP-7 expression did not differ between HPV-positive and HPV-negative patients. MMP-7 was not prognostic among patients with HPV-negative OPSCC. In the HPV-positive subgroup, patients with moderate, high, or very high MMP-7 expression had significantly worse 5-year disease-specific survival (DSS) (56.6%) than patients with absent, or low MMP-7 expression (77.2%), and MMP-7 expression appeared as a prognostic factor in the multivariate analysis. In addition, among HPV-positive OPSCC with moderate, high, or very high MMP-7 expression, the 5-year distant recurrence-free survival was significantly lower (69.6%) than in those who had low or absent MMP-7 expression (97.5%). Our results suggest that among HPV-positive OPSCC patients, high MMP-7 expression is related to worse 5-year DSS and increased rate of distant recurrences.

Indexed as

PapillomaviridaeAdultAgedCarcinoma, Squamous CellFemaleHead and Neck NeoplasmsHumansMaleMatrix Metalloproteinase 7Middle AgedNeoplasm Recurrence, LocalOropharyngeal NeoplasmsPapillomavirus InfectionsSquamous Cell Carcinoma of Head and NeckMatrix Metalloproteinase 7MMP7 protein, humanHPVMatrix metalloproteinase-7MMP-7Oropharyngeal cancerSurvival analysis

Identifiers

PMID29721609

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.