ArticlePediatric radiology2018
Optimization of magnetization-prepared rapid gradient echo (MP-RAGE) sequence for neonatal brain MRI.
Article in Pediatric radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Optimizing variable flip angles in magnetization-prepared gradient-echo sequences for efficient 3D-T1ρ mapping.Magnetic resonance in medicine · 2023Article
- Accelerated 3D T2-weighted images using compressed sensing for pediatric brain imaging.Neuroradiology · 2022Article
- Highly accelerated 3D MPRAGE using deep neural network-based reconstruction for brain imaging in children and young adults.European radiology · 2022Article
- Wave-controlled aliasing in parallel imaging magnetization-prepared gradient echo (wave-CAIPI MPRAGE) accelerates speed for pediatric brain MRI with comparable diagnostic performance.Scientific reports · 2021Article
- Objectively Diagnosed Diffuse White Matter Abnormality at Term Is an Independent Predictor of Cognitive and Language Outcomes in Infants Born Very Preterm.The Journal of pediatrics · 2020Article
- Optimization of magnetization-prepared rapid gradient echo (MP-RAGE) sequence for neonatal brain MRI.Pediatric radiology · 2018Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundSequence optimization in neonates might improve detection sensitivity of abnormalities for a variety of conditions. However this has been historically challenging because tissue properties such as the longitudinal relaxation time and proton density differ significantly between neonates and adults.
objectiveTo optimize the magnetization-prepared rapid gradient echo (MP-RAGE) sequence to enhance both signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) efficiencies. MATERIALS AND
methodsWe optimized neonatal MP-RAGE sequence through (1) reducing receive bandwidth to decrease noise, (2) shortening acquisition train length (acquisition number per repetition time or total number of read-out radiofrequency rephrasing pulses) using slice partial Fourier acquisition and (3) simulating the solution of Bloch's equation under optimal receive bandwidth and acquisition train length. Using the optimized sequence parameters, we scanned 12 healthy full-term infants within 2 weeks of birth and four preterm infants at 40 weeks' corrected age.
resultsCompared with a previously published neonatal protocol, we were able to reduce the total scan time by reduce the total scan time by 60% and increase the average SNR efficiency by 160% (P<0.001) and the average CNR efficiency by 26% (P=0.029).
conclusionOur in vivo neonatal brain imaging experiments confirmed that both SNR and CNR efficiencies significantly increased with our proposed protocol. Our proposed optimization methodology could be readily extended to other populations (e.g., older children, adults), as well as different organ systems, field strengths and MR sequences.
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