ArticleArchives of toxicology2018
Prenatal arsenic exposure and dietary folate and methylcobalamin supplementation alter the metabolic phenotype of C57BL/6J mice in a sex-specific manner.
Article in Archives of toxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 50 citations in OpenAlex.
- Diabetogenic effects of arsenic exposure in C57BL/6 N mice carrying the human AS3MT gene: the role of sex and exposure window.Archives of toxicology · 2026Article
- Dietary folate supplementation modifies effects of arsenic exposure on DNA methylation profiles in sperm of mice expressing the human AS3MT.Archives of toxicology · 2026Article
- Prenatal exposure to essential and toxic elements in relation to infant growth trajectories.Environmental health : a global access science source · 2026Article
- Metabolism of inorganic arsenic in mice carrying the human AS3MT gene and fed folate deficient or folate supplemented diet.Toxicology and applied pharmacology · 2025Article
- Metabolic Derangement by Arsenic: a Review of the Mechanisms.Biological trace element research · 2024Review
- Sex-specific transgenerational effects of preconception exposure to arsenite: metabolic phenotypes of C57BL/6 offspring.Archives of toxicology · 2023Article
- Altered cord blood mitochondrial DNA content and prenatal exposure to arsenic metabolites in low-arsenic areas.Research square · 2023Article
- Sex differences in paternal arsenic-induced intergenerational metabolic effects are mediated by estrogen.Cell & bioscience · 2023Article
- Effects of Gestational Arsenic Exposures on Placental and Fetal Development in Mice: The Role ofEnvironmental health perspectives · 2023Article
- Maternal DNA methylation signatures of arsenic exposure is associated with adult offspring insulin resistance in the Strong Heart Study.Environment international · 2023Article
- Intergenerational arsenic exposure on the mouse epigenome and metabolic physiology.Environmental and molecular mutagenesis · 2023Article
- An interaction of inorganic arsenic exposure with body weight and composition on type 2 diabetes indicators in Diversity Outbred mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Article
- Ex vivo exposures to arsenite and its methylated trivalent metabolites alter gene transcription in mouse sperm cells.Toxicology and applied pharmacology · 2022Article
- Is Arsenic Exposure a Risk Factor for Metabolic Syndrome? A Review of the Potential Mechanisms.Frontiers in endocrinology · 2022Review
- Influence of Dietary Compounds on Arsenic Metabolism and Toxicity. Part I-Animal Model Studies.Toxics · 2021Review
- Arsenic Secondary Methylation Capacity Is Inversely Associated with Arsenic Exposure-Related Muscle Mass Reduction.International journal of environmental research and public health · 2021Article
- Article
- Nutrition, one-carbon metabolism and arsenic methylation.Toxicology · 2021Review
- Inter- and Transgenerational Effects of Paternal Exposure to Inorganic Arsenic.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Diverse genetic backgrounds play a prominent role in the metabolic phenotype of CC021/Unc and CC027/GeniUNC mice exposed to inorganic arsenic.Toxicology · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Inorganic arsenic (iAs) is an established environmental diabetogen. The link between iAs exposure and diabetes is supported by evidence from adult human cohorts and adult laboratory animals. The contribution of prenatal iAs exposure to the development of diabetes and underlying mechanisms are understudied. The role of factors that modulate iAs metabolism and toxicity in adults and their potential to influence diabetogenic effects of prenatal iAs exposure are also unclear. The goal of this study was to determine if prenatal exposure to iAs impairs glucose metabolism in mice and if maternal supplementation with folate and methylcobalamin (B12) can modify this outcome. C57BL/6J dams were exposed to iAs in drinking water (0, 100, and 1000 µg As/L) and fed a folate/B12 adequate or supplemented diet from before mating to birth of offspring. After birth, dams and offspring drank deionized water and were fed the folate/B12 adequate diet. The metabolic phenotype of offspring was assessed over the course of 14 weeks. Male offspring from iAs-exposed dams fed the folate/B12-adequate diet developed fasting hyperglycemia and insulin resistance. Maternal folate/B12 supplementation rescued this phenotype but had only marginal effects on iAs metabolism in dams. The diabetogenic effects of prenatal iAs exposure in male offspring were not associated with changes in global DNA methylation in the liver. Only minimal effects of prenatal iAs exposure or maternal supplementation were observed in female offspring. These results suggest that prenatal iAs exposure impairs glucose metabolism in a sex-specific manner and that maternal folate/B12 supplementation may improve the metabolic phenotype in offspring. Further studies are needed to identify the mechanisms underlying these effects.
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