Evidence map›Paper›PMID 29721409›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2018

In Situ Monitoring of MicroRNA Replacement Efficacy and Accurate Imaging-Guided Cancer Therapy through Light-Up Inter-Polyelectrolyte Nanocomplexes.

Xiongwei Deng, Zhaoxia Yin, Jianqing Lu, Xianlei Li, Leihou Shao, Caiyan Zhao, Yishu Yang, Qin Hu, Yan Wu, Wang Sheng

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 38 citations in OpenAlex.

  1. MiRNA-based drugs: challenges and delivery strategies.Applied microbiology and biotechnology · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Nanoscale delivery systems for microRNAs in cancer therapy.Cellular and molecular life sciences : CMLS · 2020
    Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xiongwei DengCollege of Life Science and Bioengineering Beijing University of Technology No. 100 Pingleyuan Beijing 100124 P. R. China.
Zhaoxia YinCollege of Life Science and Bioengineering Beijing University of Technology No. 100 Pingleyuan Beijing 100124 P. R. China.
Jianqing LuNational Center for Nanoscience and Technology No. 11 Beiyitiao Zhongguancun Beijing 100190 P. R. China.
Xianlei LiNational Center for Nanoscience and Technology No. 11 Beiyitiao Zhongguancun Beijing 100190 P. R. China.
Leihou ShaoNational Center for Nanoscience and Technology No. 11 Beiyitiao Zhongguancun Beijing 100190 P. R. China.
Caiyan ZhaoNational Center for Nanoscience and Technology No. 11 Beiyitiao Zhongguancun Beijing 100190 P. R. China.
Yishu YangCollege of Life Science and Bioengineering Beijing University of Technology No. 100 Pingleyuan Beijing 100124 P. R. China.
Qin HuCollege of Life Science and Bioengineering Beijing University of Technology No. 100 Pingleyuan Beijing 100124 P. R. China.
Yan WuNational Center for Nanoscience and Technology No. 11 Beiyitiao Zhongguancun Beijing 100190 P. R. China.
Wang ShengCollege of Life Science and Bioengineering Beijing University of Technology No. 100 Pingleyuan Beijing 100124 P. R. China.
Beijing University of Chemical Technology · CNNational Center for Nanoscience and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Replacement of downregulated tumor-suppressive microRNA (Ts-miRNA) is recognized as an alternative approach for tumor gene therapy. However, in situ monitoring of miRNA replacement efficacy in a real-time manner via noninvasive imaging is continually challenging. Here, glutathione (GSH)-activated light-up peptide-polysaccharide-inter-polyelectrolyte nanocomplexes are established through self-assembly of carboxymethyl dextran with disulfide-bridged ("S-S") oligoarginine peptide (S-Arg

Indexed as

glutathioneimaging‐guided therapyin situ monitoringinter‐polyelectrolyte nanocomplexesmicroRNA‐34a

Identifiers

PMID29721409
PMCPMC5908377
OpenAlexW2792005550

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.