ArticleRegeneration (Oxford, England)2018
High throughput measurement of metabolism in planarians reveals activation of glycolysis during regeneration.
Article in Regeneration (Oxford, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The trial behind it
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Who cites it
28 citing papers in PubMed.
- Timing of exposure impacts how organophosphorus pesticides affect the developing brain in the planarian Dugesia japonica.Archives of toxicology · 2026Article
- Spinal cord injury induces mitochondrial dysfunction and metabolic reprogramming in non-regenerativeiScience · 2026Article
- Signal control during tissue regeneration in adult animals.Nature reviews. Molecular cell biology · 2026Review
- Metabolic reprogramming regulates histone lactylation during zebrafish caudal fin regeneration.iScience · 2026Article
- Rapid behavioral screening in the planarianFrontiers in toxicology · 2026Article
- miR-210 overexpression increases pressure overload-induced cardiac fibrosis.Non-coding RNA research · 2025Article
- Article
- Oxygen consumption rate of flatworms under the influence of wake- and sleep-promoting neurotransmitters.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2024Article
- Why study sleep in flatworms?Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Review
- Adaptation of Glucose Metabolism to Limb Autotomy and Regeneration in the Chinese Mitten Crab.Marine biotechnology (New York, N.Y.) · 2024Article
- Metabolic switches during development and regeneration.Development (Cambridge, England) · 2023Review
- Persistence of Nocturnality in Decapitated and Bisected Flatworms.Journal of biological rhythms · 2023Article
- Emerging roles of mitochondria in animal regeneration.Cell regeneration (London, England) · 2023Review
- Elevated pentose phosphate pathway flux supports appendage regeneration.Cell reports · 2022Article
- Article
- Metabolic Determinants of Cardiomyocyte Proliferation.Stem cells (Dayton, Ohio) · 2022Article
- Differences in neurotoxic outcomes of organophosphorus pesticides revealedFrontiers in toxicology · 2022Article
- Considerations for using isolated cell systems to understand cardiac metabolism and biology.Journal of molecular and cellular cardiology · 2021Review
- Unlocking mammalian regeneration through hypoxia inducible factor one alpha signaling.Biomaterials · 2021Review
- Scleraxis-lineage cell depletion improves tendon healing and disrupts adult tendon homeostasis.eLife · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Planarians are outstanding models for studying mechanisms of regeneration; however, there are few methods to measure changes in their metabolism. Examining metabolism in planarians is important because the regenerative process is dependent on numerous integrated metabolic pathways, which provide the energy required for tissue repair as well as the ability to synthesize the cellular building blocks needed to form new tissue. Therefore, we standardized an extracellular flux analysis method to measure mitochondrial and glycolytic activity in live planarians during normal growth as well as during regeneration. Small, uninjured planarians showed higher rates of oxygen consumption compared with large planarians, with no difference in glycolytic activity; however, glycolysis increased during planarian regeneration. Exposure of planarians to koningic acid, a specific inhibitor of glyceraldehyde-3-phosphate dehydrogenase, completely abolished extracellular acidification with little effect on oxygen consumption, which suggests that the majority of glucose catabolized in planarians is fated for aerobic glycolysis. These studies describe a useful method for measuring respiration and glycolysis in planarians and provide data implicating changes in glucose metabolism in the regenerative response.
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Registered trials
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