ArticleFrontiers in zoology2018
Meta-populational demes constitute a reservoir for large MHC allele diversity in wild house mice (
Article in Frontiers in zoology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Regional Lassa virus lineages select for divergent MHC-I repertoires in Mastomys natalensis rodents.PLoS pathogens · 2026Article
- Beyond the laboratory: the bank vole (Clethrionomys glareolus) as a novel model organism in biological research.Frontiers in zoology · 2025Review
- Effects of diet quality on the musculoskeletal system of the masticatory apparatus in Mus musculus domesticus.The Journal of experimental biology · 2025Article
- Article
- Food quality influences behavioural flexibility and cognition in wild house mice.Scientific reports · 2024Article
- MHC-I alleles mediate clearance and antibody response to the zoonotic Lassa virus in Mastomys rodent reservoirs.PLoS neglected tropical diseases · 2024Article
- Competitive ability is a fast-evolving trait between house mouse populations (Mus musculus domesticus).Frontiers in zoology · 2022Article
- Article
- Population Genomics of the House Mouse and the Brown Rat.Methods in molecular biology (Clifton, N.J.) · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe MHC class I and II loci mediate the adaptive immune response and belong to the most polymorphic loci in vertebrate genomes. In fact, the number of different alleles in a given species is often so large that it remains a challenge to provide an evolutionary model that can fully account for this.
resultsWe provide here a general survey of MHC allele numbers in house mouse populations and two sub-species (
conclusionsDemes can act as sources of alleles that outnumber the set of alleles that are shared across the species range. These findings support the reservoir model proposed for human MHC diversity, which states that large pools of rare MHC allele variants are continuously generated by neutral mutational mechanisms. Given that these can become important in the defense against newly emerging pathogens, the reservoir model complements the selection based models for MHC diversity and explains why the exceptional diversity exists.
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Registered trials
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