Evidence map›Paper›PMID 29721020›Full record

ArticleAdvances in virology2018

Detection of HIV-1 and Human Proteins in Urinary Extracellular Vesicles from HIV+ Patients.

Samuel I Anyanwu, Akins Doherty, Michael D Powell, Chamberlain Obialo, Ming B Huang, Alexander Quarshie, Claudette Mitchell, Khalid Bashir, Gale W Newman

Open access · goldAbstract read
In one paragraph

Article in Advances in virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Article
  6. Genome-wide association study reveals genetic variants associated with HIV-1C infection in a Botswana study population.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  7. Emerging Role of Nef in the Development of HIV Associated Neurological Disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021
    Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Proteomic Profiling of Exosomes Derived from Plasma of HIV-Infected Alcohol Drinkers and Cigarette Smokers.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Article
  13. Review
  14. Review
  15. Article
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  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Samuel I AnyanwuDepartment of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA, USA.
Akins DohertyDepartment of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA, USA.
Michael D PowellDepartment of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA, USA.
Chamberlain ObialoDepartment of Medicine, Morehouse School of Medicine, Atlanta, GA, USA.
Ming B HuangDepartment of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA, USA.
Alexander QuarshieClinical Research Center, Morehouse School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-0096-8391
Claudette MitchellDepartment of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA, USA.
Khalid BashirDepartment of Medicine, Morehouse School of Medicine, Atlanta, GA, USA.
Gale W NewmanDepartment of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-3167-891X
Morehouse School of Medicine · US

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Morehouse School of Medicine Center of Excellence Research Endowment ProgramS21MD000101 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI MONTGOMERY-RICE, VALERIE C. · 2001 to 2015
$74.3M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Research Desogn and Biostatistics CoreU54MD007588 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI MAYBERRY, ROBERT M · 2012 to 2018
$24.8M
TISSUE CULTURE MODEL FOR RETINITIS PIGMENTOSA--A MOLECULAR APPROACHR25GM058268 · NIGMS · MOREHOUSE SCHOOL OF MEDICINE · PI HARRIS-HOOKER, SANDRA, STILES, JONATHAN K. · 1998 to 2023
$16.5M
Morehouse School of Medicine MEB2 Renovation and Research Core ConsolidationG20RR031196 · NCRR · MOREHOUSE SCHOOL OF MEDICINE · PI MONTGOMERY-RICE, VALERIE C. · 2010 to 2010
$9.9M
RENOV OF MEDICAL SCI &EDUCATION BLDGS: RETINAL CELLSC06RR018386 · NCRR · MOREHOUSE SCHOOL OF MEDICINE · PI SULLIVAN, LOUIS W. · 2002 to 2002
$1.3M
NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1 TR002378NCRR NIH HHS C06 RR018386NCRR NIH HHS G20 RR031196NIGMS NIH HHS R25 GM058268NIMHD NIH HHS S21 MD000101NIMHD NIH HHS U54 MD007588
6 · The paper itself

Abstract

backgroundExtracellular vesicles (EVs) are membrane bound, secreted by cells, and detected in bodily fluids, including urine, and contain proteins, RNA, and DNA. Our goal was to identify HIV and human proteins (HPs) in urinary EVs from HIV+ patients and compare them to HIV- samples.

methodsUrine samples were collected from HIV+ (

resultsEVs from urine were 30-400 nm in size. More EVs were in HIV+ patients,

conclusionDifferences in the proteomic profile of EVs from HIV+ versus HIV- samples were found. HIV and HPs in EVs could be used to detect infection and/or diagnose HIV disease syndromes.

Identifiers

PMID29721020
PMCPMC5867598
OpenAlexW2792482838

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.