Trial reportNeural plasticity2018
Biomarkers of Rehabilitation Therapy Vary according to Stroke Severity.
Trial report in Neural plasticity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of repetitive transcranial magnetic stimulation on upper limb motor recovery after stroke: an overview of systematic reviews.Frontiers in neurologyPooled it
- Test-retest reliability and minimal detectable change of corticospinal tract integrity in chronic stroke.Human brain mapping · 2020Trial
- Hebbian-Type Primary Motor Cortex Stimulation: A Potential Treatment of Impaired Hand Function in Chronic Stroke Patients.Neurorehabilitation and neural repair · 2020Trial
- Towards AI-based precision rehabilitation via contextual model-based reinforcement learning.Journal of neuroengineering and rehabilitation · 2025Article
- Article
- Brain-Hand Function Relationships Based on Level of Grasp Function in Chronic Left-Hemisphere Stroke.Neurorehabilitation and neural repair · 2024Article
- Identifying biomarkers related to motor function in chronic stroke: A fNIRS and TMS study.CNS neuroscience & therapeutics · 2024Article
- A Method for Estimating Longitudinal Change in Motor Skill from Individualized Functional-Connectivity Measures.Sensors (Basel, Switzerland) · 2022Article
- Functional connectivity drives stroke recovery: shifting the paradigm from correlation to causation.Brain : a journal of neurology · 2022Review
- Cortical Oxygenation during a Motor Task to Evaluate Recovery in Subacute Stroke Patients: A Study with Near-Infrared Spectroscopy.Neurology international · 2022Article
- Performance Comparison of Different Neuroimaging Methods for Predicting Upper Limb Motor Outcomes in Patients after Stroke.Neural plasticity · 2022Article
- Article
- Recovery and Prediction of Bimanual Hand Use After Stroke.Neurology · 2021Observational
- Comparison of corticospinal tract integrity measures extracted from standard versus native space in chronic stroke.Journal of neuroscience methods · 2021Article
- Neuromechanical Biomarkers for Robotic Neurorehabilitation.Frontiers in neurorobotics · 2021Review
- Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Biomarkers that capture treatment effects could improve the precision of clinical decision making for restorative therapies. We examined the performance of candidate structural, functional, and angiogenesis-related MRI biomarkers before and after a 3-week course of standardized robotic therapy in 18 patients with chronic stroke and hypothesized that results vary significantly according to stroke severity. Patients were 4.1 ± 1 months poststroke, with baseline arm Fugl-Meyer scores of 20-60. When all patients were examined together, no imaging measure changed over time in a manner that correlated with treatment-induced motor gains. However, when also considering the interaction with baseline motor status, treatment-induced motor gains were significantly related to change in three functional connectivity measures: ipsilesional motor cortex connectivity with (1) contralesional motor cortex (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.