Evidence map›Paper›PMID 29720976›Full record

ArticleFrontiers in immunology2018

Carbonate Apatite Nanoparticles Act as Potent Vaccine Adjuvant Delivery Vehicles by Enhancing Cytokine Production Induced by Encapsulated Cytosine-Phosphate-Guanine Oligodeoxynucleotides.

Hideki Takahashi, Kazuki Misato, Taiki Aoshi, Yasuyuki Yamamoto, Yui Kubota, Xin Wu, Etsushi Kuroda, Ken J Ishii, Hirofumi Yamamoto, Yasuo Yoshioka

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Hideki TakahashiVaccine Creation Project, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Kazuki MisatoVaccine Creation Project, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Taiki AoshiVaccine Dynamics Project, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Yasuyuki YamamotoVaccine Creation Project, BIKEN Center for Innovative Vaccine Research and Development, The Research Foundation for Microbial Diseases of Osaka University, Suita, Japan.
Yui KubotaDivision of Health Sciences, Department of Molecular Pathology, Graduate School of Medicine, Osaka University, Suita, Japan.
Xin WuDivision of Health Sciences, Department of Molecular Pathology, Graduate School of Medicine, Osaka University, Suita, Japan.
Etsushi KurodaLaboratory of Adjuvant Innovation, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan.
Ken J IshiiLaboratory of Adjuvant Innovation, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan.
Hirofumi YamamotoDivision of Health Sciences, Department of Molecular Pathology, Graduate School of Medicine, Osaka University, Suita, Japan.
Yasuo YoshiokaVaccine Creation Project, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Osaka University · JPKyoto Biken Laboratories (Japan) · JPNational Institute of Biomedical Innovation, Health and Nutrition · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccine adjuvants that can induce not only antigen-specific antibody responses but also Th1-type immune responses and CD8

Indexed as

NanoparticlesAdjuvants, ImmunologicAnimalsApatitesCytokinesDrug CarriersHumansMiceOligodeoxyribonucleotidesVaccinesAdjuvants, ImmunologicApatitescarboapatiteCPG-oligonucleotideCytokinesDrug CarriersOligodeoxyribonucleotidesVaccinesadjuvantcytosine-phosphate-guanine oligodeoxynucleotideinfluenza virusinterferon-αnanoparticlevaccine

Identifiers

PMID29720976
PMCPMC5916113
OpenAlexW2801325884

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.