Evidence map›Paper›PMID 29720965›Full record

ReviewFrontiers in endocrinology2018

Mechanisms of Aerobic Exercise Impairment in Diabetes: A Narrative Review.

Matthew P Wahl, Rebecca L Scalzo, Judith G Regensteiner, Jane E B Reusch

Abstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Observational
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Matthew P WahlDivision of Endocrinology, University of Colorado School of Medicine, Aurora, CO, United States.
Rebecca L ScalzoDivision of Endocrinology, University of Colorado School of Medicine, Aurora, CO, United States.
Judith G RegensteinerCenter for Women's Health Research, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, United States.
Jane E B ReuschDivision of Endocrinology, University of Colorado School of Medicine, Aurora, CO, United States.

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$61.3M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6M
Translational Pulmonary Vascular Biology ProgramT32HL007171 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Sonia Castro Flores, Tim Lahm · 1985 to 2026
$9.4M
Targeting Microvascular Contributors to Impaired Functional Exercise Capacity in DiabetesI01BX002046 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI REUSCH, JANE E · 2014 to 2024
–
Cardiovascular Mechanisms of Exercise Intolerance in Diabetes and the Role of SexI01CX001532 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI REUSCH, JANE E · 2017 to 2022
–
BLRD VA I01 BX002046CSRD VA I01 CX001532NCRR NIH HHS UL1 RR025780NHLBI NIH HHS T32 HL007171NIDDK NIH HHS P30 DK048520
6 · The paper itself

Abstract

The prevalence of diabetes in the United States and globally has been rapidly increasing over the last several decades. There are now estimated to be 30.3 million people in the United States and 422 million people worldwide with diabetes. Diabetes is associated with a greatly increased risk of cardiovascular mortality, which is the leading cause of death in adults with diabetes. While exercise training is a cornerstone of diabetes treatment, people with diabetes have well-described aerobic exercise impairments that may create an additional diabetes-specific barrier to adding regular exercise to their lifestyle. Physiologic mechanisms linked to exercise impairment in diabetes include insulin resistance, cardiac abnormalities, mitochondrial function, and the ability of the body to supply oxygen. In this paper, we highlight the abnormalities of exercise in type 2 diabetes as well as potential therapeutic approaches.

Indexed as

insulin resistancemicrovascularmitochondrial dysfunctionmuscle perfusionnitric oxide synthase

Identifiers

PMID29720965
PMCPMC5915473

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.