ReviewFrontiers in endocrinology2018
Sex Differences in Medium Spiny Neuron Excitability and Glutamatergic Synaptic Input: Heterogeneity Across Striatal Regions and Evidence for Estradiol-Dependent Sexual Differentiation.
Review in Frontiers in endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 59 citations in OpenAlex.
- Synaptic Actions of Estradiol in the Brain's Reward System: Linking Mechanisms to Behavior and Disease.Biological psychiatry global open science · 2026Review
- Sex-dependent behavioral and hypothalamic receptor changes after early-life monosodium glutamate (MSG) exposure and adult social stress in Wistar rats.Metabolic brain disease · 2026Article
- Divergent Roles of Nucleus Accumbens D1- and D2-MSNs in Regulating Hedonic Feeding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Alcohol-induced accumbal dopamine- and taurine release in female and male Wistar rats, an in vivo microdialysis study.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Article
- Dorsomedial Striatum CB1R signaling is required for Pavlovian outcome devaluation in male Long Evans rats and reduces inhibitory synaptic transmission in both sexes.bioRxiv : the preprint server for biology · 2024Article
- Sex-Specific Mechanisms Underlie Long-Term Potentiation at Hippocampus→Medium Spiny Neuron Synapses in the Medial Shell of the Nucleus Accumbens.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Sex differences in the distribution and density of regulatory interneurons in the striatum.bioRxiv : the preprint server for biology · 2024Article
- Article
- Sex differences in the distribution and density of regulatory interneurons in the striatum.Frontiers in cellular neuroscience · 2024Article
- Review
- Sex differences in mouse infralimbic cortex projections to the nucleus accumbens shell.Biology of sex differences · 2023Article
- Proteomic association with age-dependent sex differences in Wisconsin Card Sorting Test performance in healthy Thai subjects.Scientific reports · 2023Article
- Neurosteroids and the mesocorticolimbic system.Neuroscience and biobehavioral reviews · 2023Review
- Comparison of Huntington's disease phenotype progression in male and female heterozygous FDNQ175 mice.Molecular brain · 2023Article
- Article
- Transient effects of junk food on NAc core MSN excitability and glutamatergic transmission in obesity-prone female rats.Obesity (Silver Spring, Md.) · 2023Article
- Role of Hormones in Substance Use Disorders.Neuroendocrinology · 2023Article
- Sex Chromosome Complement and Estradiol Modify Cocaine Self-Administration Behaviors in Male Mice.Neuroendocrinology · 2023Article
- Striatal Neurons Partially Expressing a Dopaminergic Phenotype: Functional Significance and Regulation.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Steroid sex hormones and biological sex influence how the brain regulates motivated behavior, reward, and sensorimotor function in both normal and pathological contexts. Investigations into the underlying neural mechanisms have targeted the striatal brain regions, including the caudate-putamen, nucleus accumbens core (AcbC), and shell. These brain regions are of particular interest to neuroendocrinologists given that they express membrane-associated but not nuclear estrogen receptors, and also the well-established role of the sex steroid hormone 17β-estradiol (estradiol) in modulating striatal dopamine systems. Indeed, output neurons of the striatum, the medium spiny neurons (MSNs), exhibit estradiol sensitivity and sex differences in electrophysiological properties. Here, we review sex differences in rat MSN glutamatergic synaptic input and intrinsic excitability across striatal regions, including evidence for estradiol-mediated sexual differentiation in the nucleus AcbC. In prepubertal animals, female MSNs in the caudate-putamen exhibit a greater intrinsic excitability relative to male MSNs, but no sex differences are detected in excitatory synaptic input. Alternatively, female MSNs in the nucleus AcbC exhibit increased excitatory synaptic input relative to male MSNs, but no sex differences in intrinsic excitability were detected. Increased excitatory synaptic input onto female MSNs in the nucleus AcbC is abolished after masculinizing estradiol or testosterone exposure during the neonatal critical period. No sex differences are detected in MSNs in prepubertal nucleus accumbens shell. Thus, despite possessing the same neuron type, striatal regions exhibit heterogeneity in sex differences in MSN electrophysiological properties, which likely contribute to the sex differences observed in striatal function.
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