ArticleFrontiers in physiology2018
Decrease of Perivascular Adipose Tissue Browning Is Associated With Vascular Dysfunction in Spontaneous Hypertensive Rats During Aging.
Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Peroxisomal dysfunction in cardiac adipose tissue is involved in obesity-associated cardiac hypertrophy.Journal of advanced research · 2026Article
- The adipose tissue-plaque crosstalk: omics profiling of perivascular adipose tissues for understanding plaque stability.Cardiovascular diabetology · 2026Review
- The Dual Role of Perivascular Adipose Tissue in Vascular Homeostasis and Atherogenesis: From Physiology to Pathological Implications.International journal of molecular sciences · 2025Review
- The Implications of Aging on Vascular Health.International journal of molecular sciences · 2024Review
- The role of brown adipose tissue in mediating healthful longevity.The journal of cardiovascular aging · 2024Article
- Cross-talks between perivascular adipose tissue and neighbors: multifaceted nature of nereids.Frontiers in pharmacology · 2024Review
- Perivascular adipose tissue in vascular pathologies-a novel therapeutic target for atherosclerotic disease?Frontiers in cardiovascular medicine · 2023Review
- Endothelial Nitric Oxide Synthase in the Perivascular Adipose Tissue.Biomedicines · 2022Review
- Roles of Perivascular Adipose Tissue in Hypertension and Atherosclerosis.Antioxidants & redox signaling · 2021Review
- Aging Affects KFrontiers in physiology · 2021Article
- MiR-3064 in Epicardial Adipose-Derived Exosomes Targets Neuronatin to Regulate Adipogenic Differentiation of Epicardial Adipose Stem Cells.Frontiers in cardiovascular medicine · 2021Article
- Site-specific impairment of perivascular adipose tissue on advanced atherosclerotic plaques using multimodal nonlinear optical imaging.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Suppression of Brown Adipocyte Autophagy Improves Energy Metabolism by Regulating Mitochondrial Turnover.International journal of molecular sciences · 2019Article
- PPARMediators of inflammation · 2019Article
- Perivascular Adipose Tissue-Enhanced Vasodilation in Metabolic Syndrome Rats by Apelin andInternational journal of molecular sciences · 2018Article
- Adipose Tissue and Modulation of Hypertension.Current hypertension reports · 2018Review
- Plasticity of Adipose Tissue-Derived Stem Cells and Regulation of Angiogenesis.Frontiers in physiology · 2018Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional perivascular adipose tissue (PVAT) is necessary to maintain vascular physiology through both mechanical support and endocrine or paracrine ways. PVAT shows a brown adipose tissue (BAT)-like feature and the browning level of PVAT is dependent on the anatomic location and species. However, it is not clear whether PVAT browning is involved in the vascular tone regulation in spontaneously hypertensive rats (SHRs). In the present study, we aimed to illustrate the effect of aging on PVAT browning and subsequent vasomotor reaction in SHRs. Herein we utilized histological staining and western blot to detect the characteristics of thoracic PVAT (tPVAT) in 8-week-old and 16-week-old SHR and Wistar-Kyoto (WKY) rats. We also detected vascular reactivity analysis to determine the effect of tPVAT on vasomotor reaction during aging. The results showed that tPVAT had a similar phenotype to BAT, including smaller adipocyte size and positive uncoupling protein-1 (UCP1) staining. Interestingly, the tPVAT of 8-week-old SHR showed increased BAT phenotypic marker expression compared to WKY, whereas the browning level of tPVAT had a more dramatic decrease from 8 to 16 weeks of age in SHR than age-matched WKY rats. The vasodilation effect of tPVAT on aortas had no significant difference in 8-week-old WKY and SHR, whereas this effect is obviously decreased in 16-week-old SHR compared to WKY. In contrast, tPVAT showed a similar vasoconstriction effect in 8- or 16-week-old WKY and SHR rats. Moreover, we identified an important vasodilator adenosine, which regulates adipocyte browning and may be a potential PVAT-derived relaxing factor. Adenosine is dramatically decreased from 8 to 16 weeks of age in the tPVAT of SHR. In summary, aging is associated with a decrease of tPVAT browning and adenosine production in SHR rats. These may result in attenuated vasodilation effect of the tPVAT in SHR during aging.
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