Evidence map›Paper›PMID 29720934›Full record

ReviewFrontiers in neural circuits2018

Reticulospinal Systems for Tuning Motor Commands.

Robert M Brownstone, Jeremy W Chopek

Abstract readReview
In one paragraph

Review in Frontiers in neural circuits, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed.

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  5. Enhanced Reticulospinal Output in Subacute Spinal Cord Injury Patients with Spasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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  18. Hyperactive delta isoform of PI3 kinase enables long-distance regeneration of adult rat corticospinal tract.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Robert M BrownstoneSobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London London, United Kingdom.
Jeremy W ChopekSobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London London, United Kingdom.

Funding

Wellcome Trust 110193Wellcome Trust 110193/Z/15/Z
6 · The paper itself

Abstract

The pontomedullary reticular formation (RF) is a key site responsible for integrating descending instructions to execute particular movements. The indiscrete nature of this region has led not only to some inconsistencies in nomenclature, but also to difficulties in understanding its role in the control of movement. In this review article, we first discuss nomenclature of the RF, and then examine the reticulospinal motor command system through evolution. These command neurons have direct monosynaptic connections with spinal interneurons and motoneurons. We next review their roles in postural adjustments, walking and sleep atonia, discussing their roles in movement activation or inhibition. We propose that knowledge of the internal organization of the RF is necessary to understand how the nervous system tunes motor commands, and that this knowledge will underlie strategies for motor functional recovery following neurological injuries or diseases.

Indexed as

AnimalsHumansInterneuronsLocomotionMotor NeuronsNeural PathwaysReticular FormationSpinal Cordlocomotionmesencephalic locomotor regionmicrocircuitsreticular formationsleep atonia

Identifiers

PMID29720934
PMCPMC5915564

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.