Evidence map›Paper›PMID 29720871›Full record

ArticleDrug design, development and therapy2018

Islet protection and amelioration of type 2 diabetes mellitus by treatment with quercetin from the flowers of

Manjiao Zhuang, Honghong Qiu, Ping Li, Lihua Hu, Yayu Wang, Lei Rao

Open access · goldAbstract read
In one paragraph

Article in Drug design, development and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
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  10. Qihu Preparation Ameliorates Diabetes by Activating the AMPK Signaling Pathway in db/db Mice.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Manjiao ZhuangDepartment of Pharmacy, Sichuan University, Chengdu, People's Republic of China.
Honghong QiuCollaborative Innovation Center of Sichuan for Elderly Care and Health, Chengdu Medical College, Chengdu, China.
Ping LiCollaborative Innovation Center of Sichuan for Elderly Care and Health, Chengdu Medical College, Chengdu, China.
Lihua HuCollaborative Innovation Center of Sichuan for Elderly Care and Health, Chengdu Medical College, Chengdu, China.
Yayu WangDepartment of Cell Biology, Institute of Biological Medicine, Jinan University, Guangzhou, People's Republic of China.
Lei RaoCollaborative Innovation Center of Sichuan for Elderly Care and Health, Chengdu Medical College, Chengdu, China.
Chengdu Medical College · CNJinan University · CNSichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThe traditional Chinese medicine - the flower of

methodQuercetin was extracted from the flowers of

resultsA quercetin level of >10 μmol/L could induce insulin secretion. Intracellular Ca

conclusionOur study indicated that quercetin extracted from the flowers of

Indexed as

AnimalsAntioxidantsApoptosisCells, CulturedCell SurvivalDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2FlowersHumansInsulinMedicine, Chinese TraditionalMembrane Potential, MitochondrialMiceMice, Inbred C57BLMice, ObesePalmitic AcidAntioxidantsInsulinPalmitic AcidQuercetinanti-apoptosisEdgeworthia gardneriinsulin secretionquercetintype 2 diabetes mellitus

Identifiers

PMID29720871
PMCPMC5918626
OpenAlexW2799719911

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.