Evidence map›Paper›PMID 29720769›Full record

ArticleMonatshefte fur chemie2018

The influence of physical division of tablets on the variability of release kinetics of gliclazide.

Dorota Wójcik-Pastuszka, Anna M Biedrawa, Dorota Haznar-Garbacz, Witold S Musiał

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Monatshefte fur chemie, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Dorota Wójcik-Pastuszka1Department of Physical Chemistry, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland.
Anna M Biedrawa1Department of Physical Chemistry, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland.
Dorota Haznar-Garbacz2Department of Drug Form Technology, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland.
Witold S Musiał1Department of Physical Chemistry, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland.
Wroclaw Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractTablets are often used in splitting process when the appropriated, registered dose is not available on the market or patients exhibit swallowing difficulties caused by the size of the tablet. The aim of the work was to assess the impact of physical division of tablets on the kinetics of in vitro gliclazide release from the intact and divided tablets. Gliclazide was released from prolonged release tablets containing 30 or 60 mg of the drug into a phosphate buffer, pH 7.4 and the amount of the drug in acceptor fluid was determined by UV-Vis spectrophotometry. The dissolution profiles were fit to zero- and first-order kinetics as well as to the Korsmeyer-Peppas equation. The largest discrepancy in the values of rate constants was obtained in the case of the release of gliclazide from intact and from splitting tablets using zero- and first-order kinetics. The values of the rate constants GRAPHICAL ABSTRACT:

Indexed as

GliclazideKineticsOral hypoglycemic agentsPharmacopoeial dissolution testTablets formulationUV–Vis spectroscopy

Identifiers

PMID29720769
PMCPMC5915509
OpenAlexW2793649973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.