ArticleIndian journal of anaesthesia2018
Effect site concentration of propofol at induction and recovery of anaesthesia - A correlative dose-response study.
Article in Indian journal of anaesthesia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Comparison of Nitroglycerin versus Lignocaine Spray to Attenuate Haemodynamic Changes in Elective Surgical Patients Undergoing Direct Laryngoscopy and Endotracheal Intubation: A prospective randomised study.Sultan Qaboos University medical journal · 2019Trial
- Indian expert consensus on intra-operative consciousness monitoring using processed electroencephalogram-based indices: A Delphi-based approach.Indian journal of anaesthesia · 2026Article
- An implementation of integrated information theory in resting-state fMRI.Communications biology · 2023Article
- Recovery time in target controlled infusion versus manual infusion of propofol in total intravenous anaesthesia for endoscopic retrograde cholangio-pancreatography procedure using laryngeal mask airway-gastro: A randomised comparative study.Indian journal of anaesthesia · 2023Article
- To ascertain the plasma concentration of propofol to achieve bispectral index-guided sedation using a target-controlled infusion in patients undergoing elective surgeries under neuraxial anaesthesia.Indian journal of anaesthesia · 2022Article
- Effect-site concentration of remimazolam at loss and recovery of responsiveness during general anesthesia: a simulation study.Anesthesia and pain medicine · 2022Article
- Concurrent brain and lung hydatid cyst in a paediatric patient: Anaesthetic challenges.Indian journal of anaesthesia · 2020Article
- Target controlled infusion total intravenous anaesthesia and Indian patients: Do we need our own data?Indian journal of anaesthesia · 2018Article
- A comparative observational study on the effect of two different doses of fentanyl on the effect site concentration of propofol during induction of anesthesia using clinical assessment score and bispectral index.Journal of anaesthesiology, clinical pharmacologyArticle
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3 authors.
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Abstract
BACKGROUND AND
aimsSound knowledge about effect site concentration (Ce) of propofol aids in smooth induction, maintenance and early recovery. We studied the correlation between Ce of propofol at loss of response to verbal command and recovery concentration using target-controlled infusion (TCI) in Indian patients who underwent spine surgeries.
methodsNinety patients undergoing spine surgeries were included. Total intravenous anaesthesia (TIVA) technique with TCI for propofol using modified Marsh model was used. Entropy and neuromuscular transmission were used. Ce at induction and recovery and the corresponding state entropy (SE) values were noted.
resultsThe mean propofol Ce and SE at induction were 2.34 ± 0.24 μg/ml and 52 ± 8, respectively. The mean propofol Ce and SE at recovery were 1.02 ± 0.22 μg/ml and 86.80 ± 2.86, respectively. The Ce at recovery was approximately 50% of the induction value. The correlation coefficient '
conclusionThere is a positive correlation between Ce at induction and recovery. Ce for recovery may have to be set at a lower level during TCI-TIVA and appropriately infusion should be stopped for early recovery. The induction and maintenance doses of propofol are lower than the recommended doses. Data emphasise the need for pharmacokinetic model based on our population characteristics.
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