Evidence map›Paper›PMID 29720735›Full record

ReviewLeukemia2018

Prevention and management of adverse events of novel agents in multiple myeloma: a consensus of the European Myeloma Network.

Heinz Ludwig, Michel Delforge, Thierry Facon, Hermann Einsele, Francesca Gay, Philippe Moreau, Hervé Avet-Loiseau, Mario Boccadoro, Roman Hajek, Mohamad Mohty and 22 more

Open access · hybridAbstract readConsensus StatementReview
In one paragraph

Review in Leukemia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 20 institutions in 14 countries.

Heinz LudwigWilhelminen Cancer Research Institute, Vienna, Austria. heinz.ludwig@wienkav.at.
Michel DelforgeDepartment of Hematology, University Hospital Leuven, Catholic University Leuven, Leuven, Belgium.
Thierry FaconDepartment of Hematology, Lille University Hospital, Lille, France.
Hermann EinseleDepartment of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.
Francesca GayMyeloma Unit, Division of Hematology, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, University of Torino, Torino, Italy.
Philippe MoreauDepartment of Hematology, University Hospital, University of Nantes, Nantes, France.
Hervé Avet-LoiseauCentre de Recherches en Cancerologie de Toulouse CRCT, Institut National de la Sante et de la Recherche Medicale, Université Toulouse, Toulouse, France.
Mario BoccadoroDivision of Hematology, Citta della Salute e della Scienza, University of Torino, Torino, Italy.
Roman HajekFaculty of Medicine, University Hospital Ostrava, University of Ostrava, Ostrava, Czech Republic.
Mohamad MohtyDepartment of Haematology, Saint Antoine Hospital, University Pierre and Marie Curie, and INSERM UMRs 938, Paris, France.
Michele CavoA 'Seràgnoli' Institute of Hematology, Bologna University School of Medicine, Bologna, Italy.
Meletios A DimopoulosDepartment of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Jesús F San-MiguelDepartment of Hematology, Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada (CIMA), IDISNA, CIBERONC, Pamplona, Spain.
Evangelos TerposDepartment of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Sonja ZweegmanDepartment of Hematology, VU University Medical Center, Amsterdam, The Netherlands.
Laurent GarderetDepartment of Haematology, Saint Antoine Hospital, University Pierre and Marie Curie, and INSERM UMRs 938, Paris, France.
María-Victoria MateosHospital Universitario de Salamanca, Instituto Biosanitario de Salamanca (IBSAL), Salamanca, Spain.
Gordon CookLeeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
Xavier LeleuService d'Hématologie et Thérapie Cellulaire, PRC, and Inserm CIC1402, Hospital de la Miléterie, Poitiers, France.
Hartmut GoldschmidtNational Center for Tumor Diseases, Heidelberg Medical University, Heidelberg, Germany.
Graham JacksonDepartment of Hematology, Newcastle University, Newcastle, UK.
Martin KaiserMyeloma Group, The Institute of Cancer Research ICR, London, UK.
Katja WeiselDepartment of Hematology and Oncology, University of Tuebingen, Tuebingen, Germany.
Niels W C J van de DonkDepartment of Hematology, VU University Medical Center, Amsterdam, The Netherlands.
Anders WaageDepartment of Hematology, St. Olavs Hospital, and IKOM, NTNU, Trondheim, Norway.
Meral BeksacDepartment of Medicine, Ankara University, Ankara, Turkey.ORCID http://orcid.org/0000-0003-1797-8657
Ulf H MellqvistDepartment of Hematology, Sahlgrenska Hospital, Gothenburg, Sweden.
Monika EngelhardtDepartment of Hematology and Oncology, University of Freiburg Medical Center, Freiburg, Germany.
Jo CaersDepartment of Hematology, University Hospital of Liège, Liège, Belgium.
Christoph DriessenDepartment of Oncology and Hematology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
Joan BladéDepartment of Hematology, Amyloidosis and Myeloma Unit, Hospital Clínic de Barcelona, Spain.
Pieter SonneveldDepartment of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Inserm · FRAmsterdam UMC Location Vrije Universiteit Amsterdam · NLAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITNational and Kapodistrian University of Athens · GRAnkara University · TRCentre de Recherche en Cancérologie de Toulouse · FRClinica Universidad de Navarra · ESErasmus MC Cancer Institute · NLHospital Clínic de Barcelona · ESInstitute of Cancer Research · GBInstituto de Investigación Biomédica de Salamanca · ESKantonsspital St. Gallen · CHKU Leuven · BELille’s Cardiology Hospital · FRNantes Université · FRNational Center for Tumor Diseases · DENewcastle University · GBSahlgrenska University Hospital · SESt Olav's University Hospital · NOUniversitätsklinikum Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During the last few years, several new drugs have been introduced for treatment of patients with multiple myeloma, which have significantly improved the treatment outcome. All of these novel substances differ at least in part in their mode of action from similar drugs of the same drug class, or are representatives of new drug classes, and as such present with very specific side effect profiles. In this review, we summarize these adverse events, provide information on their prevention, and give practical guidance for monitoring of patients and for management of adverse events.

Indexed as

Antineoplastic AgentsDisease ManagementDrug-Related Side Effects and Adverse ReactionsHumansIncidenceMolecular Targeted TherapyMultiple MyelomaRisk AssessmentAntineoplastic Agents

Identifiers

PMID29720735
PMCPMC6035147
OpenAlexW2778713062

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.