Evidence map›Paper›PMID 29720725›Full record

ArticleOncogene2018

Inhibition of GPR158 by microRNA-449a suppresses neural lineage of glioma stem/progenitor cells and correlates with higher glioma grades.

Ningning Li, Ying Zhang, Kastytis Sidlauskas, Matthew Ellis, Ian Evans, Paul Frankel, Joanne Lau, Tedani El-Hassan, Loredana Guglielmi, Jessica Broni and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogene, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

  1. Osteocalcin and GPR158: linking bone and brain function.Frontiers in cell and developmental biology · 2025
    Review
  2. Article
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  5. Article
  6. Review
  7. Review
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  9. The emerging roles of GPR158 in the regulation of the endocrine system.Frontiers in cell and developmental biology · 2022
    Review
  10. Article
  11. Article
  12. Whole-exome sequencing,American journal of cancer research · 2021
    Article
  13. Article
  14. Article
  15. Identification ofCancers · 2019
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Ningning LiDepartment of Neurodegeneration, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK. linn29@mail.sysu.edu.cn.
Ying ZhangDepartment of Neurodegeneration, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.
Kastytis SidlauskasDepartment of Neurodegeneration, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.
Matthew EllisDepartment of Neurodegeneration, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.
Ian EvansDivision of Medicine, University College London, University Street, London, WC1E 6JF, UK.
Paul FrankelDivision of Medicine, University College London, University Street, London, WC1E 6JF, UK.
Joanne LauDepartment of Neurodegeneration, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.
Tedani El-HassanDivision of Neuropathology, the National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust Queen Square, London, WC1N 3BG, UK.
Loredana GuglielmiBlizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK.
Jessica BroniDepartment of Neurodegeneration, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.
Angela Richard-LoendtDepartment of Neurodegeneration, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.
Sebastian BrandnerDepartment of Neurodegeneration, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK. s.brandner@ucl.ac.uk.ORCID http://orcid.org/0000-0002-9821-0342
National Hospital for Neurology and Neurosurgery · GBUniversity College London · GBUniversity College London Hospitals NHS Foundation Trust · GBQueen Mary University of London · GBSun Yat-sen University · CN

Funding

Cancer Research UK 23615Cancer Research UK A20256Cancer Research UK A23615Department of Health UCLBRC-2012-1
6 · The paper itself

Abstract

To identify biomarkers for glioma growth, invasion and progression, we used a candidate gene approach in mouse models with two complementary brain tumour phenotypes, developing either slow-growing, diffusely infiltrating gliomas or highly proliferative, non-invasive primitive neural tumours. In a microRNA screen we first identified microRNA-449a as most significantly differentially expressed between these two tumour types. miR-449a has a target dependent effect, inhibiting cell growth and migration by downregulation of CCND1 and suppressing neural phenotypes by inhibition of G protein coupled-receptor (GPR) 158. GPR158 promotes glioma stem cell differentiation and induces apoptosis and is highest expressed in the cerebral cortex and in oligodendrogliomas, lower in IDH mutant astrocytomas and lowest in the most malignant form of glioma, IDH wild-type glioblastoma. The correlation of GPR158 expression with molecular subtypes, patient survival and therapy response suggests a possible role of GPR158 as prognostic biomarker in human gliomas.

Indexed as

AnimalsApoptosisAstrocytomaBiomarkers, TumorBrain NeoplasmsCell DifferentiationCell Line, TumorCell MovementCell ProliferationDown-RegulationGlioblastomaGliomaHumansMiceMicroRNAsOligodendrogliomaBiomarkers, TumorGPR158 protein, mouseMicroRNAsMirn449 microRNA, mouseReceptors, G-Protein-CoupledTranscription Factors

Identifiers

PMID29720725
PMCPMC6072706
OpenAlexW2799518067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.