ArticleScientific reports2018
N-Alkylation of functionalized amines with alcohols using a copper-gold mixed photocatalytic system.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 54 citations in OpenAlex.
- β-Scission of Tertiary Alcohols on a Platinum-Loaded Titanium Dioxide Photocatalyst for C─C Bond-Forming Reactions.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Room-Temperature Metal-Catalyzed Hydrogen Borrowing Alkylation.ACS catalysis · 2026Review
- Installation of d3-methyl group to drugs by continuous-flow solid-phase synthesis.Nature communications · 2025Article
- Mechanochemistry-Driven Borrowing Hydrogen Processes for Ru-Catalyzed N-Alkylation: A Pathway to Enhanced Sustainability and Efficiency.Angewandte Chemie (International ed. in English) · 2025Article
- Iridium-catalyzed α-selective deuteration of alcohols.Chemical science · 2022Article
- SelectiveACS omega · 2021Article
- Synthetic Approaches for C-N Bonds by TiOFrontiers in chemistry · 2019Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Direct functionalization of amino groups in complex organic molecules is one of the most important key technologies in modern organic synthesis, especially in the synthesis of bio-active chemicals and pharmaceuticals. Whereas numerous chemical reactions of amines have been developed to date, a selective, practical method for functionalizing complex amines is still highly demanded. Here we report the first late-stage N-alkylation of pharmaceutically relevant amines with alcohols at ambient temperature. This reaction was achieved by devising a mixed heterogeneous photocatalyst in situ prepared from Cu/TiO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.