ArticleJCI insight2018
Unexpected kidney-restricted role for IL-17 receptor signaling in defense against systemic Candida albicans infection.
Article in JCI insight, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- A multimarker panel for diagnosis and prognosis prediction of fungal infections.Clinical and experimental medicine · 2026Article
- Diagnostic efficiency of inflammatory signatures to distinguish isolated candidemia from candidemia with bacterial co-infection.Frontiers in immunology · 2025Article
- The RNA binding protein Arid5a drives IL-17-dependent autoantibody-induced glomerulonephritis.The Journal of experimental medicine · 2024Article
- Diffuse Endocapillary Glomerulonephritis in a Child With IL-17RA Deficiency Emphasizes the Pivotal Role of the Complement Cascade and Anaphylatoxins.Kidney international reports · 2023Article
- Inflammatory ER stress responses dictate the immunopathogenic progression of systemic candidiasis.The Journal of clinical investigation · 2023Article
- SARS-CoV-2 ORF8 Mediates Signals in Macrophages and Monocytes through MyD88 Independently of the IL-17 Receptor.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- The Interleukine-17 Cytokine Family: Role in Development and Progression of Spondyloarthritis, Current and Potential Therapeutic Inhibitors.Biomedicines · 2023Review
- Pathogenesis and virulence ofVirulence · 2022Review
- Deep tissue infection by an invasive human fungal pathogen requires lipid-based suppression of the IL-17 response.Cell host & microbe · 2022Article
- Arid5a Mediates an IL-17-Dependent Pathway That Drives Autoimmunity but Not Antifungal Host Defense.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Th17/Regulatory T-Cell Imbalance and Acute Kidney Injury in Patients with Sepsis.Journal of clinical medicine · 2022Article
- Potential of Polyethyleneimine as an Adjuvant To Prepare Long-Term and Potent Antifungal Nanovaccine.Frontiers in immunology · 2022Article
- The hepatocyte growth factor/c-met pathway is a key determinant of the fibrotic kidney local microenvironment.iScience · 2021Article
- Local antifungal immunity in the kidney in disseminated candidiasis.Current opinion in microbiology · 2021Review
- RTEC-intrinsic IL-17-driven inflammatory circuit amplifies antibody-induced glomerulonephritis and is constrained by Regnase-1.JCI insight · 2021Article
- The mScience immunology · 2021Article
- T helper 17 cells in the pathophysiology of acute and chronic kidney disease.Kidney research and clinical practice · 2021Article
- Vaccine-Induced Immunological Memory in Invasive Fungal Infections - A Dream so Close yet so Far.Frontiers in immunology · 2021Review
- Recognition ofMicroorganisms · 2020Review
- STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells.EMBO molecular medicine · 2020Article
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6 authors at 1 institution in 1 country.
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Abstract
Kidney injury is a frequent outcome in patients with disseminated Candida albicans fungal infections. IL-17 receptor (IL-17R) signaling is critical for renal protection against disseminated candidiasis, but the identity and function of IL-17-responsive cells in mediating renal defense remains an active area of debate. Using BM chimeras, we found that IL-17R signaling is required only in nonhematopoietic cells for immunity to systemic C. albicans infection. Since renal tubular epithelial cells (RTEC) are highly responsive to IL-17 in vitro, we hypothesized that RTEC might be the dominant target of IL-17 activity in the infected kidney. We generated mice with a conditional deletion of IL-17 receptor A (Il17ra) in RTEC (Il17raΔRTEC). Strikingly, Il17raΔRTEC mice showed enhanced kidney damage and early mortality following systemic infection, very similar to Il17ra-/- animals. Increased susceptibility to candidiasis in Il17raΔRTEC mice was associated with diminished activation of the renal protective Kallikrein-kinin system (KKS), resulting in reduced apoptosis of kidney-resident cells during hyphal invasion. Moreover, protection was restored by treatment with bradykinin, the major end-product of KKS activation, which was mediated dominantly via bradykinin receptor b1. These data show that IL-17R signaling in RTEC is necessary and likely sufficient for IL-17-mediated renal defense against fatal systemic C. albicans infection.
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