Evidence map›Paper›PMID 29720522›Full record

ReviewJournal of virology2018

Complexities of Viral Mutation Rates.

Kayla M Peck, Adam S Lauring

Abstract readReview
In one paragraph

Review in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 244 papers.

0numbers the graph read from it
0cells of the map it votes in
244citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

244 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Dislodging the drift barrier: Why do mutation rates vary?Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Mutation rate variability in viral populations: Implications for lethal mutagenesis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  15. Article
  16. Phylogeny Building for Structural Phylogenomic Research.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  17. Article
  18. Article
  19. Article
  20. Article

184 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kayla M PeckDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0001-7745-6995
Adam S LauringDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA alauring@med.umich.edu.ORCID https://orcid.org/0000-0003-2906-8335

Funding

Molecular Mechanisms of Microbial Pathogenesis Training ProgramT32AI007528 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 1998 to 2024
$6.8M
Fidelity, robustness, and diversity in RNA virus evolution and pathogenesisR01AI118886 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LAURING, ADAM · 2016 to 2020
$2.0M
NIAID NIH HHS R01 AI118886NIAID NIH HHS T32 AI007528
6 · The paper itself

Abstract

Many viruses evolve rapidly. This is due, in part, to their high mutation rates. Mutation rate estimates for over 25 viruses are currently available. Here, we review the population genetics of virus mutation rates. We specifically cover the topics of mutation rate estimation, the forces that drive the evolution of mutation rates, and how the optimal mutation rate can be context-dependent.

Indexed as

Evolution, MolecularMutationMutation RateHumansVirusesVirus Replicationmutation rate evolutionpolymerasepolymerase fidelityviral mutation ratesvirus evolution

Identifiers

PMID29720522
PMCPMC6026756

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.