Evidence map›Paper›PMID 29720474›Full record

ArticleDisease models & mechanisms2018

Functional and genomic characterisation of a xenograft model system for the study of metastasis in triple-negative breast cancer.

Cameron N Johnstone, Andrew D Pattison, Kylie L Gorringe, Paul F Harrison, David R Powell, Peter Lock, David Baloyan, Matthias Ernst, Alastair G Stewart, Traude H Beilharz and 1 more

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.4field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
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  6. Article
  7. Loss ofInternational journal of molecular sciences · 2023
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  9. Measuring the tail: Methods for poly(A) tail profiling.Wiley interdisciplinary reviews. RNA · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. The In Vivo Selection Method in Breast Cancer Metastasis.International journal of molecular sciences · 2021
    Review
  16. Article
  17. Article
  18. Article
  19. KISS1 in breast cancer progression and autophagy.Cancer metastasis reviews · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Cameron N JohnstoneCancer Research Division, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Parkville, Victoria 3050, Australia cameron.johnstone@onjcri.org.au traude.beilharz@monash.edu robin.anderson@onjcri.org.au.ORCID 0000-0002-6464-8661
Andrew D PattisonDepartment of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
Kylie L GorringeCancer Research Division, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Parkville, Victoria 3050, Australia.ORCID 0000-0001-5681-2022
Paul F HarrisonMonash Bioinformatics Platform, Monash University, Clayton, Victoria 3800, Australia.
David R PowellBiomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
Peter LockLIMS Bioimaging Facility, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria 3086, Australia.ORCID 0000-0003-4421-3609
David BaloyanOlivia Newton-John Cancer Research Institute, Heidelberg, Victoria 3084, Australia.
Matthias ErnstOlivia Newton-John Cancer Research Institute, Heidelberg, Victoria 3084, Australia.
Alastair G StewartDepartment of Pharmacology & Therapeutics, University of Melbourne, Parkville, Victoria 3010, Australia.
Traude H BeilharzDepartment of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia cameron.johnstone@onjcri.org.au traude.beilharz@monash.edu robin.anderson@onjcri.org.au.ORCID 0000-0002-8942-9502
Robin L AndersonCancer Research Division, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Parkville, Victoria 3050, Australia cameron.johnstone@onjcri.org.au traude.beilharz@monash.edu robin.anderson@onjcri.org.au.ORCID 0000-0002-6841-7422
The University of Melbourne · AUAustralian Regenerative Medicine Institute · AULa Trobe University · AUMonash University · AUOlivia Newton-John Cancer Wellness & Research Centre · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) represents 10-20% of all human ductal adenocarcinomas and has a poor prognosis relative to other subtypes. Hence, new molecular targets for therapeutic intervention are necessary. Analyses of panels of human or mouse cancer lines derived from the same individual that differ in their cellular phenotypes but not in genetic background have been instrumental in defining the molecular players that drive the various hallmarks of cancer. To determine the molecular regulators of metastasis in TNBC, we completed a rigorous

Indexed as

GenomicsXenograft Model Antitumor AssaysAnimalsBone Morphogenetic Protein 4CattleCell CycleCell Line, TumorCystatin MDNA Copy Number VariationsDNA MethylationDNA, NeoplasmGene Expression ProfilingGene Expression Regulation, NeoplasticHistone Deacetylase InhibitorsHumansNeoplasm MetastasisBone Morphogenetic Protein 4Cst6 protein, mouseCystatin MDNA, NeoplasmHistone Deacetylase InhibitorsRNA, MessengerBreast cancerMetastasisMouse modelTriple-negativeXenograft

Identifiers

PMID29720474
PMCPMC5992606
OpenAlexW2801826986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.