Evidence map›Paper›PMID 29720442›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Metabolic control of T cell immune response through glycans in inflammatory bowel disease.

Ana M Dias, Alexandra Correia, Márcia S Pereira, Catarina R Almeida, Inês Alves, Vanda Pinto, Telmo A Catarino, Nuno Mendes, Magdalena Leander, M Teresa Oliva-Teles and 10 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 109 citations in OpenAlex.

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  7. Alterations in mucosa branchedGut microbes · 2025
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Ana M DiasInstitute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal.
Alexandra CorreiaInstitute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal.
Márcia S PereiraInstitute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal.
Catarina R AlmeidaInstitute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal.
Inês AlvesInstitute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal.
Vanda PintoInstitute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal.
Telmo A CatarinoInstitute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal.
Nuno MendesInstitute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal.
Magdalena LeanderHematology Department, Centro Hospitalar do Porto, 4099-001 Porto, Portugal.
M Teresa Oliva-TelesREQUIMTE/LAQV, Instituto Superior de Engenharia, Instituto Politécnico do Porto, 4200-072 Porto, Portugal.
Luís MaiaDepartment of Gastroenterology, Centro Hospitalar do Porto, Porto, Portugal.
Cristina Delerue-MatosREQUIMTE/LAQV, Instituto Superior de Engenharia, Instituto Politécnico do Porto, 4200-072 Porto, Portugal.
Naoyuki TaniguchiDisease Glycomics Team, RIKEN, Tokyo 351-0198, Japan.
Margarida LimaHematology Department, Centro Hospitalar do Porto, 4099-001 Porto, Portugal.
Isabel PedrotoDepartment of Gastroenterology, Centro Hospitalar do Porto, Porto, Portugal.
Ricardo Marcos-PintoInstitute of Biomedical Sciences of Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal.
Paula LagoDepartment of Gastroenterology, Centro Hospitalar do Porto, Porto, Portugal.
Celso A ReisInstitute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal.ORCID 0000-0002-0286-6639
Manuel VilanovaInstitute of Biomedical Sciences of Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal.
Salomé S PinhoInstitute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal; salomep@ipatimup.pt.
Universidade do Porto · PTCentro Hospitalar do Porto · PTRede de Química e Tecnologia · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mucosal T lymphocytes from patients with ulcerative colitis (UC) were previously shown to display a deficiency in branched N-glycosylation associated with disease severity. However, whether this glycosylation pathway shapes the course of the T cell response constituting a targeted-specific mechanism in UC remains largely unknown. In this study, we demonstrated that metabolic supplementation of ex vivo mucosal T cells from patients with active UC with

Indexed as

AcetylglucosamineAdaptive ImmunityAnimalsCase-Control StudiesCD4-Positive T-LymphocytesColitis, UlcerativeCytokinesGlycosylationHumansLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutN-AcetylglucosaminyltransferasesPolysaccharidesReceptors, Antigen, T-CellAcetylglucosaminealpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferaseCytokinesN-AcetylglucosaminyltransferasesPolysaccharidesReceptors, Antigen, T-Celladaptive immune responsebranched N-glycosylationintestinal inflammationT cell receptorT lymphocytes

Identifiers

PMID29720442
PMCPMC5960299
OpenAlexW2799516656

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.