Evidence map›Paper›PMID 29720426›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

MicroRNA-155 Modulates Acute Graft-versus-Host Disease by Impacting T Cell Expansion, Migration, and Effector Function.

Nina C Zitzer, Katiri Snyder, Xiamoei Meng, Patricia A Taylor, Yvonne A Efebera, Steven M Devine, Bruce R Blazar, Ramiro Garzon, Parvathi Ranganathan

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Role of miR-155 in inflammatory autoimmune diseases: a comprehensive review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Pooled it
  2. Article
  3. Review
  4. Article
  5. The Role of MicroRNA in the Pathogenesis of Atopic Dermatitis.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Epigenetic regulation of CD8Frontiers in immunology · 2025
    Review
  8. Review
  9. Article
  10. The absence of AhR in CD4Clinical epigenetics · 2022
    Article
  11. Article
  12. IL-36β promotes anti-tumor effects in CD8Annals of translational medicine · 2021
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Nina C ZitzerDivision of Hematology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.ORCID 0000-0001-9098-635X
Katiri SnyderDivision of Hematology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.
Xiamoei MengDivision of Hematology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.
Patricia A TaylorMasonic Cancer Center, University of Minnesota, Minneapolis, MN 55455; and.
Yvonne A EfeberaDivision of Hematology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.ORCID 0000-0002-4163-8823
Steven M DevineDivision of Hematology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.
Bruce R BlazarMasonic Cancer Center, University of Minnesota, Minneapolis, MN 55455; and.ORCID 0000-0002-9608-9841
Ramiro GarzonDivision of Hematology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.
Parvathi RanganathanDivision of Hematology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210; parvathi.ranganathan@osumc.edu.
The Ohio State University · USUniversity of Minnesota · US

Funding

ONOCOLOGY TRAINING GRANTT32CA009338 · NCI · OHIO STATE UNIVERSITY · PI BYRD, JOHN C., POLLOCK, RAPHAEL E. · 1985 to 2018
$8.3M
Enhancing Treg Therapeutic Efficacy in GVHDR01HL118979 · NHLBI · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, HIPPEN, KELI L · 2014 to 2025
$6.7M
IN VIVO PREVENTION OF MURINE GVHDR01AI034495 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BLAZAR, BRUCE R · 1993 to 2016
$6.2M
T-CELL TARGETING FOR GVHDR01HL056067 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BLAZAR, BRUCE R · 1995 to 2022
$5.4M
In Vivo Prevention of Murine GVHDR37AI034495 · NIAID · UNIVERSITY OF MINNESOTA · PI Bruce R Blazar · 2017 to 2026
$5.4M
T CELL TARGETING FOR GVHDR37HL056067 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BLAZAR, BRUCE R. · 1998 to 2007
$3.2M
MicroRNAs as biomarkers for acute graft-versus-host diseaseR21HL117707 · NHLBI · OHIO STATE UNIVERSITY · PI EFEBERA, YVONNE A., GARZON, RAMIRO · 2013 to 2014
$228k
NCI NIH HHS T32 CA009338NHLBI NIH HHS R01 HL056067NHLBI NIH HHS R01 HL118979NHLBI NIH HHS R21 HL117707NHLBI NIH HHS R37 HL056067NIAID NIH HHS R01 AI034495NIAID NIH HHS R37 AI034495
6 · The paper itself

Abstract

MicroRNA-155 (miR-155) is a small noncoding RNA critical for the regulation of inflammation as well as innate and adaptive immune responses. MiR-155 has been shown to be dysregulated in both donor and recipient immune cells during acute graft-versus-host disease (aGVHD). We previously reported that miR-155 is upregulated in donor T cells of mice and humans with aGVHD and that mice receiving miR-155-deficient (miR155

Indexed as

Acute DiseaseAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell MovementCell ProliferationColonGraft vs Host DiseaseInterleukin-2 Receptor alpha SubunitLymphocyte ActivationMiceMice, Inbred C57BLMicroRNAsReceptors, CCR5Receptors, CXCR4SpleenInterleukin-2 Receptor alpha SubunitMicroRNAsMirn155 microRNA, mouseReceptors, CCR5Receptors, CXCR4

Identifiers

PMID29720426
PMCPMC5988971
OpenAlexW2802341018

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.