Evidence map›Paper›PMID 29720420›Full record

ArticleOpen biology2018

The contribution of non-essential

Shervi Lie, Peter Banks, Conor Lawless, David Lydall, Janni Petersen

Open access · goldAbstract read
In one paragraph

Article in Open biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. High-Throughput, High-Precision Colony Phenotyping with Pyphe.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. eLife · 2020
    Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Shervi LieFlinders Centre for Innovation in Cancer, College of Medicine & Public Health, Flinders University, Bedford Park, Adelaide, South Australia 5042, Australia.
Peter BanksHigh Throughput Screening Facility, Newcastle Biomedicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Conor LawlessInstitute for Cell & Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne NE2 4HH, UK.
David LydallInstitute for Cell & Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne NE2 4HH, UK.
Janni PetersenFlinders Centre for Innovation in Cancer, College of Medicine & Public Health, Flinders University, Bedford Park, Adelaide, South Australia 5042, Australia janni.petersen@flinders.edu.au.ORCID 0000-0003-0729-9335
Newcastle University · GBFlinders University · AU

Funding

Cancer Research UK 13314Medical Research Council MR/L001284/1Worldwide Cancer Research 16-0052
6 · The paper itself

Abstract

Nutrient fluctuations in the cellular environment promote changes in cell metabolism and growth to adapt cell proliferation accordingly. The target of rapamycin (TOR) signalling network plays a key role in the coordination of growth and cell proliferation with the nutrient environment and, importantly, nutrient limitation reduces TOR complex 1 (TORC1) signalling. We have performed global quantitative fitness profiling of the collection of

Indexed as

Genetic FitnessConserved SequenceGene DeletionGene Expression Regulation, FungalGene Regulatory NetworksHumansMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2NaphthyridinesNitrogenSchizosaccharomycesSchizosaccharomyces pombe ProteinsStress, Physiological1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-oneMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2NaphthyridinesNitrogenSchizosaccharomyces pombe Proteinsnutrient stressSchizosaccharomyces pombeTORC1TORC2Torin1TOR substrates

Identifiers

PMID29720420
PMCPMC5990653
OpenAlexW2802579176

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.