Evidence map›Paper›PMID 29720266›Full record

ReviewStem cell research & therapy2018

α6-Integrin alternative splicing: distinct cytoplasmic variants in stem cell fate specification and niche interaction.

Zijing Zhou, Jing Qu, Li He, Hong Peng, Ping Chen, Yong Zhou

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Zijing ZhouDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Tinsley Harrison Tower 437B, 1900 University Blvd, Birmingham, AL, 35294, USA.
Jing QuDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Tinsley Harrison Tower 437B, 1900 University Blvd, Birmingham, AL, 35294, USA.
Li HeDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Tinsley Harrison Tower 437B, 1900 University Blvd, Birmingham, AL, 35294, USA.
Hong PengDepartment of Respiratory Medicine, The Second Xiangya Hospital, Central-South University, Changsha, 410011, Hunan, China.
Ping ChenDepartment of Respiratory Medicine, The Second Xiangya Hospital, Central-South University, Changsha, 410011, Hunan, China.
Yong ZhouDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Tinsley Harrison Tower 437B, 1900 University Blvd, Birmingham, AL, 35294, USA. yongzhou@uabmc.edu.
University of Alabama at Birmingham · USCentral South University · CN

Funding

Targeting Matrix Stiffness in Lung Fibrosis Associated with AgingR01HL139584 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZHOU, YONG · 2018 to 2024
$2.2M
Optic Nerve Head Mechanobiology in GlaucomaR01EY027924 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DOWNS, J CRAWFORD, MURPHY-ULLRICH, JOANNE E · 2018 to 2021
$1.8M
The Role of Biomechanical Signaling in Lung FibrosisR01HL124076 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZHOU, YONG · 2015 to 2018
$1.5M
Central South University 2016zzts144China Scholarship Council 201706370106NEI NIH HHS EY027924NEI NIH HHS R01 EY027924NHLBI NIH HHS HL124076NHLBI NIH HHS R01 HL124076NHLBI NIH HHS R01 HL139584School of Medicine, University of Alabama at Birmingham AMC21 R01 Award
6 · The paper itself

Abstract

α6-Integrin subunit (also known as CD49f) is a stemness signature that has been found on the plasma membrane of more than 30 stem cell populations. A growing body of studies have focused on the critical role of α6-containing integrins (α6β1 and α6β4) in the regulation of stem cell properties, lineage-specific differentiation, and niche interaction. α6-Integrin subunit can be alternatively spliced at the post-transcriptional level, giving rise to divergent isoforms which differ in the cytoplasmic and/or extracellular domains. The cytoplasmic domain of integrins is an important functional part of integrin-mediated signals. Structural changes in the cytoplasmic domain of α6 provide an efficient means for the regulation of stem cell responses to biochemical stimuli and/or biophysical cues in the stem cell niche, thus impacting stem cell fate determination. In this review, we summarize the current knowledge on the structural variants of the α6-integrin subunit and spatiotemporal expression of α6 cytoplasmic variants in embryonic and adult stem/progenitor cells. We highlight the roles of α6 cytoplasmic variants in stem cell fate decision and niche interaction, and discuss the potential mechanisms involved. Understanding of the distinct functions of α6 splicing variants in stem cell biology may inform the rational design of novel stem cell-based therapies for a range of human diseases.

Indexed as

Alternative SplicingCell DifferentiationHumansIntegrin alpha6Stem CellsIntegrin alpha6Alternative splicingNicheStem cell; Stemnessα6-Integrin

Identifiers

PMID29720266
PMCPMC5930856
OpenAlexW2799722935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.