Evidence map›Paper›PMID 29720232›Full record

ArticleJournal of nanobiotechnology2018

Highly sensitive and robust peroxidase-like activity of Au-Pt core/shell nanorod-antigen conjugates for measles virus diagnosis.

Lin Long, Jianbo Liu, Kaishun Lu, Tao Zhang, Yunqing Xie, Yinglu Ji, Xiaochun Wu

Erratum issuedAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Biomedical Applications of Nanozymes: An Enzymology Perspective.Angewandte Chemie (International ed. in English) · 2025
    Review
  3. Article
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  6. Ionic liquids functionalized FeMikrochimica acta · 2023
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Lin LongZaozhuang Municipal Center for Disease Control and Prevention, Zaozhuang, 277100, China.
Jianbo LiuCollege of Opto-electronic Engineering, Zaozhuang University, Zaozhuang, 277160, China. linyibm@163.com.ORCID http://orcid.org/0000-0001-5611-5892
Kaishun LuZaozhuang Municipal Center for Disease Control and Prevention, Zaozhuang, 277100, China.
Tao ZhangZaozhuang Municipal Center for Disease Control and Prevention, Zaozhuang, 277100, China.
Yunqing XieZaozhuang Municipal Center for Disease Control and Prevention, Zaozhuang, 277100, China.
Yinglu JiCAS Key Laboratory of Standardization and Measurement for Nanotechnology, National Center for Nanoscience and Technology, Beijing, 100190, China.
Xiaochun WuCAS Key Laboratory of Standardization and Measurement for Nanotechnology, National Center for Nanoscience and Technology, Beijing, 100190, China. wuxc@nanoctr.cn.

Funding

Key Research and Development Program of Shandong Province of China 2015GSF118079National Key Basic Research Program of China 2011CB932802National Key Basic Research Program of China 2016YFA0200903National Natural Science Foundation of China 21173056National Natural Science Foundation of China 61704149National Natural Science Foundation of China 91127013Natural Science Foundation of Shandong Province of China ZR2017QA004
6 · The paper itself

Abstract

backgroundAs a promising candidate for artificial enzymes, catalytically active nanomaterials show several advantages over natural enzymes, such as controlled synthesis at low cost, tunability of catalytic activities, and high stability under stringent conditions. Rod-shaped Au-Pt core/shell nanoparticles (Au@Pt NRs), prepared by Au nanorod-mediated growth, exhibit peroxidase-like activities and could serve as an inexpensive replacement for horseradish peroxidase, with potential applications in various bio-detections. The determination of measles virus is accomplished by a capture-enzyme-linked immunosorbent assay (ELISA) using Au@Pt NR-antigen conjugates.

resultsBased on the enhanced catalytic properties of this nanozyme probe, a linear response was observed up to 10 ng/mL measles IgM antibodies in human serum, which is 1000 times more sensitive than commercial ELISA.

conclusionsHence, these findings provide positive proof of concept for the potential of Au@Pt NR-antigen conjugates in the development of colorimetric biosensors that are simple, robust, and cost-effective.

Indexed as

Antibodies, ViralAntigens, ViralEnzyme-Linked Immunosorbent AssayGoldHorseradish PeroxidaseHumansImmunoglobulin MLimit of DetectionMeaslesMeasles virusNanotubesPlatinumAntibodies, ViralAntigens, ViralGoldHorseradish PeroxidaseImmunoglobulin MPlatinumConjugateEnzyme-linked immunosorbent assay (ELISA)Gold nanorodsPeroxidase mimicPlatinumVirus diagnosis

Identifiers

PMID29720232
PMCPMC5930499

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.