Trial reportBreast cancer research : BCR2018
Assessing brain volume changes in older women with breast cancer receiving adjuvant chemotherapy: a brain magnetic resonance imaging pilot study.
Trial report in Breast cancer research : BCR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01992432 (A Pilot Study of Structural and Functional Brain Magnetic Resonance Imaging Findings of Chemotherapy Toxicity in Older Women With Breast Cancer), which is not on this map. Cited by 24 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study of Structural and Functional Brain Magnetic Resonance Imaging Findings of Chemotherapy Toxicity in Older Women With Breast Cancer
Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Chemotherapy-related cognitive impairment and non-pharmacological interventions targeting the nervous system: a systematic review.Frontiers in psychiatry · 2026Pooled it
- Cognitive impairments associated with chemotherapy in women with breast cancer: a meta-analysis and meta-regression.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023Pooled it
- The Developmental Trajectory of Cancer-Related Cognitive Impairment in Breast Cancer Patients: A Systematic Review of Longitudinal Neuroimaging Studies.Neuropsychology review · 2020Pooled it
- Structural brain alterations following adult non-CNS cancers: a systematic review of the neuroimaging literature.Acta oncologica (Stockholm, Sweden) · 2019Pooled it
- Utility of the iPad NIH Toolbox Cognition Battery in a clinical trial of older adults.Journal of the American Geriatrics Society · 2021Trial
- Changes in chemotherapy-induced cognitive impairment in gastrointestinal cancer survivors using multidomain assessments: a prospective cohort study.Journal of cancer survivorship : research and practice · 2026Article
- Altered gyrification in chemotherapy-treated older long-term breast cancer survivors.Brain and behavior · 2024Article
- Effect of chemotherapy on hippocampal volume and shape in older long-term breast cancer survivors.Frontiers in aging neuroscience · 2024Article
- Cancer-related cognitive impairment in racial and ethnic minority groups: a scoping review.Journal of cancer research and clinical oncology · 2023Article
- Remote assessment of cognitive dysfunction in hematologic malignancies using web-based neuropsychological testing.Cancer medicine · 2023Article
- A scoping review of cognitive assessment tools and domains for chemotherapy-induced cognitive impairments in cancer survivors.Frontiers in human neuroscience · 2023Article
- Chemobrain in Breast Cancer: Mechanisms, Clinical Manifestations, and Potential Interventions.Drug safety · 2022Review
- Association of a wide range of individual chronic diseases and their multimorbidity with brain volumes in the UK Biobank: A cross-sectional study.EClinicalMedicine · 2022Article
- Brain morphological alterations and their correlation to tumor differentiation and duration in patients with lung cancer after platinum chemotherapy.Frontiers in oncology · 2022Article
- Cognitive Function in Older Adults With Cancer: Assessment, Management, and Research Opportunities.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021Review
- Structural Neuroimaging Findings Related to Adult Non-CNS Cancer and Treatment: Review, Integration, and Implications for Treatment of Cognitive Dysfunction.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Cortical Brain Age from Pre-treatment to Post-chemotherapy in Patients with Breast Cancer.Neurotoxicity research · 2020Article
- Effects of chemotherapy on aging white matter microstructure: A longitudinal diffusion tensor imaging study.Journal of geriatric oncology · 2020Article
- Breast cancer and aging: Standing on the shoulders of a giant.Journal of geriatric oncology · 2020Review
- The Influence of Physical Activity and Epigenomics On Cognitive Function and Brain Health in Breast Cancer.Frontiers in aging neuroscience · 2020Review
Corrections and comments
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Authors and funding
23 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundCognitive decline is among the most feared treatment-related outcomes of older adults with cancer. The majority of older patients with breast cancer self-report cognitive problems during and after chemotherapy. Prior neuroimaging research has been performed mostly in younger patients with cancer. The purpose of this study was to evaluate longitudinal changes in brain volumes and cognition in older women with breast cancer receiving adjuvant chemotherapy.
methodsWomen aged ≥ 60 years with stage I-III breast cancer receiving adjuvant chemotherapy and age-matched and sex-matched healthy controls were enrolled. All participants underwent neuropsychological testing with the US National Institutes of Health (NIH) Toolbox for Cognition and brain magnetic resonance imaging (MRI) prior to chemotherapy, and again around one month after the last infusion of chemotherapy. Brain volumes were measured using Neuroreader™ software. Longitudinal changes in brain volumes and neuropsychological scores were analyzed utilizing linear mixed models.
resultsA total of 16 patients with breast cancer (mean age 67.0, SD 5.39 years) and 14 age-matched and sex-matched healthy controls (mean age 67.8, SD 5.24 years) were included: 7 patients received docetaxel and cyclophosphamide (TC) and 9 received chemotherapy regimens other than TC (non-TC). There were no significant differences in segmented brain volumes between the healthy control group and the chemotherapy group pre-chemotherapy (p > 0.05). Exploratory hypothesis generating analyses focusing on the effect of the chemotherapy regimen demonstrated that the TC group had greater volume reduction in the temporal lobe (change = - 0.26) compared to the non-TC group (change = 0.04, p for interaction = 0.02) and healthy controls (change = 0.08, p for interaction = 0.004). Similarly, the TC group had a decrease in oral reading recognition scores (change = - 6.94) compared to the non-TC group (change = - 1.21, p for interaction = 0.07) and healthy controls (change = 0.09, p for interaction = 0.02).
conclusionsThere were no significant differences in segmented brain volumes between the healthy control group and the chemotherapy group; however, exploratory analyses demonstrated a reduction in both temporal lobe volume and oral reading recognition scores among patients on the TC regimen. These results suggest that different chemotherapy regimens may have differential effects on brain volume and cognition. Future, larger studies focusing on older adults with cancer on different treatment regimens are needed to confirm these findings.
trial registrationClinicalTrials.gov, NCT01992432 . Registered on 25 November 2013. Retrospectively registered.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.