Evidence map›Paper›PMID 29720177›Full record

ArticleEnvironmental health : a global access science source2018

Genomic characterization of chronic lymphocytic leukemia (CLL) in radiation-exposed Chornobyl cleanup workers.

Juhi Ojha, Iryna Dyagil, Stuart C Finch, Robert F Reiss, Adam J de Smith, Semira Gonseth, Mi Zhou, Helen M Hansen, Amy L Sherborne, Jean Nakamura and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health : a global access science source, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Journal of medical genetics · 2020
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 2 countries.

Juhi OjhaSchool of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Iryna DyagilNational Research Center for Radiation Medicine, Kyiv, Ukraine.
Stuart C FinchRutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Robert F ReissDepartment of Pathology and Cell Biology, and Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Adam J de SmithSchool of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Semira GonsethSchool of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Mi ZhouSchool of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Helen M HansenSchool of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Amy L SherborneSchool of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Jean NakamuraSchool of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Paige M BracciSchool of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Nataliya GudzenkoNational Research Center for Radiation Medicine, Kyiv, Ukraine.
Maureen HatchDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Nataliya BabkinaNational Research Center for Radiation Medicine, Kyiv, Ukraine.
Mark P LittleDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Vadim V ChumakNational Research Center for Radiation Medicine, Kyiv, Ukraine.
Kyle M WalshSchool of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Dimitry BazykaNational Research Center for Radiation Medicine, Kyiv, Ukraine.
Joseph L WiemelsSchool of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Lydia B ZablotskaSchool of Medicine, University of California, San Francisco, San Francisco, CA, USA. Lydia.Zablotska@ucsf.edu.ORCID 0000-0002-0778-1108
University of California, San Francisco · USNational Academy of Medical Sciences of Ukraine · UANational Institutes of Health · USBerkeley Public Health Division · USColumbia University · USRutgers, The State University of New Jersey · US

Funding

Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6M
Studies of Populations Exposed to Occupational Sources of RadiationZIACP010133 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI KITAHARA, CARI · 2009 to 2025
$34.2M
GM-CSF - producing tumor cell line as a CML vaccineR21CA115043 · NCI · DANA-FARBER CANCER INSTITUTE · PI WU, CATHERINE JU-YING · 2005 to 2006
$654k
Risk of Leukemia after Protracted Exposures to Low Doses of Ionizing RadiationK07CA132918 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZABLOTSKA, LYDIA B · 2010 to 2013
$652k
Risk of hematologic cancers from repeated low-dose diagnostic radiationR03CA188614 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZABLOTSKA, LYDIA B · 2014 to 2015
$158k
Damon Runyon Cancer Research Foundation CI-38-07Howard Hughes Medical InstituteNCI NIH HHS 5K07CA132918NCI NIH HHS 5R03CA188614NCI NIH HHS 5R21CA115043-2NCI NIH HHS K07 CA132918NCI NIH HHS NO1-CP-2117NCI NIH HHS R03 CA188614NCI NIH HHS R21 CA115043NHGRI NIH HHS 5U54HG003067NHGRI NIH HHS U54 HG003067
6 · The paper itself

Abstract

backgroundChronic lymphocytic leukemia (CLL) was the predominant leukemia in a recent study of Chornobyl cleanup workers from Ukraine exposed to radiation (UR-CLL). Radiation risks of CLL significantly increased with increasing bone marrow radiation doses. Current analysis aimed to clarify whether the increased risks were due to radiation or to genetic mutations in the Ukrainian population.

methodsA detailed characterization of the genomic landscape was performed in a unique sample of 16 UR-CLL patients and age- and sex-matched unexposed general population Ukrainian-CLL (UN-CLL) and Western-CLL (W-CLL) patients (n = 28 and 100, respectively).

resultsMutations in telomere-maintenance pathway genes POT1 and ATM were more frequent in UR-CLL compared to UN-CLL and W-CLL (both p < 0.05). No significant enrichment in copy-number abnormalities at del13q14, del11q, del17p or trisomy12 was identified in UR-CLL compared to other groups. Type of work performed in the Chornobyl zone, age at exposure and at diagnosis, calendar time, and Rai stage were significant predictors of total genetic lesions (all p < 0.05). Tumor telomere length was significantly longer in UR-CLL than in UN-CLL (p = 0.009) and was associated with the POT1 mutation and survival.

conclusionsNo significant enrichment in copy-number abnormalities at CLL-associated genes was identified in UR-CLL compared to other groups. The novel associations between radiation exposure, telomere maintenance and CLL prognosis identified in this unique case series provide suggestive, though limited data and merit further investigation.

Indexed as

Chernobyl Nuclear AccidentOccupational ExposureRadiation ExposureAdultCase-Control StudiesFemaleFollow-Up StudiesGenome, HumanGenomicsHumansIncidenceLeukemia, Lymphocytic, Chronic, B-CellMaleMiddle AgedNeoplasms, Radiation-InducedPrevalenceChernobylChornobylChronic lymphocytic leukemiaIonizing radiationMutationTelomere

Identifiers

PMID29720177
PMCPMC5930419
OpenAlexW2801741011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.