SynthesisBMC pediatrics2018
A systematic review comparing neurodevelopmental outcome in term infants with hypoxic and vascular brain injury with and without seizures.
Synthesis in BMC pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
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Who cites it
8 citing papers in PubMed, 26 citations in OpenAlex.
- A machine-learning algorithm for neonatal seizure recognition: a multicentre, randomised, controlled trial.The Lancet. Child & adolescent health · 2020Trial
- Epilepsy in autism spectrum disorder: examining prevalence and associated factors in a large cross-sectional study.Journal of neurodevelopmental disorders · 2026Article
- The impact of clinical seizures and adverse brain MRI patterns in neonates with hypoxic-ischemic encephalopathy and abnormal neurodevelopment.Clinics (Sao Paulo, Brazil) · 2025Article
- Article
- Sustained acute kidney injury as an independent risk factor for neurodevelopmental and growth outcomes in a single NICU center.BMC pediatrics · 2024Article
- Bi-allelic variants in the ESAM tight-junction gene cause a neurodevelopmental disorder associated with fetal intracranial hemorrhage.American journal of human genetics · 2023Article
- Neonatal seizures: stepping outside the comfort zone.Clinical and experimental pediatrics · 2022Article
- Neonatal Seizure Management: Is the Timing of Treatment Critical?The Journal of pediatrics · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is increasing evidence that neonatal seizures in term neonates with stroke, asphyxia or brain haemorrhage might be associated with adverse neurodevelopment and development of epilepsy. The extent of this association is not known. The objective of this study was to assess the possible impact of neonatal seizures on these outcomes and if possible calculate a relative risk.
methodsA systematic review and meta-analysis was performed (study period January 2000-June 2015). PubMed, Medline and Embase were searched for cohort studies evaluating neurodevelopmental outcome at the age of at least 18 months or development of epilepsy in surviving term neonates with or without neonatal seizures. The methodological quality of included studies was assessed and data extractions were performed in a standardized manner by independent reviewers. Pooled Relative Risks (RR) with 95% confidence intervals for adverse outcome were calculated if possible.
resultsOut of 1443 eligible studies 48 were selected for full text reading leaving 9 cohort studies for the final analyses (4 studies on stroke, 4 on perinatal asphyxia and one on cerebral hemorrhage). For all cases with stroke or asphyxia combined the pooled risk ratio (RR) for adverse outcome when suffering neonatal seizures was 7.42 (3.84-14.34); for neonates with perinatal asphyxia: 8.41 (4.07-17.39) and for neonates with stroke: 4.95 (1.07-23.0). The pooled RR for development of late onset epilepsy could only be determined for infants suffering from stroke: 1.48 (0.82-2.68). Results were biased and evidence sparse.
conclusionsThe presence of neonatal seizures in term newborns with vascular or hypoxic brain injury may have an impact on or be a predictor of neurodevelopmental outcome. The biased available data yield insufficient evidence about the true size of this association.
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