Evidence map›Paper›PMID 29720115›Full record

ArticleBMC nephrology2018

Biomarker enhanced risk prediction for development of AKI after cardiac surgery.

Michael L Merchant, Michael E Brier, Mark S Slaughter, Jon B Klein, Kenneth R McLeish

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
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  3. The role of complement in kidney disease.Nature reviews. Nephrology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Michael L MerchantDivision of Nephrology & Hypertension, Department of Medicine, University of Louisville School of Medicine, Donald Baxter Research Building, Rm 204C, 570 S. Preston Street, Louisville, KY, 40202, USA. mlmerc02@louisville.edu.ORCID 0000-0003-4128-4057
Michael E BrierDivision of Nephrology & Hypertension, Department of Medicine, University of Louisville School of Medicine, Donald Baxter Research Building, Rm 204C, 570 S. Preston Street, Louisville, KY, 40202, USA.
Mark S SlaughterCardiovascular and Thoracic Surgery, University of Louisville School of Medicine, Louisville, USA.
Jon B KleinDivision of Nephrology & Hypertension, Department of Medicine, University of Louisville School of Medicine, Donald Baxter Research Building, Rm 204C, 570 S. Preston Street, Louisville, KY, 40202, USA.
Kenneth R McLeishDivision of Nephrology & Hypertension, Department of Medicine, University of Louisville School of Medicine, Donald Baxter Research Building, Rm 204C, 570 S. Preston Street, Louisville, KY, 40202, USA.
University of Louisville · US

Funding

Role of oxidized linoleic acid metabolites in the pathogenesis of alcoholic liver diseaseP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · PI GHARE, SMITA S · 2016 to 2025
$24.1M
NIGMS NIH HHS P20 GM113226
6 · The paper itself

Abstract

backgroundAcute kidney injury (AKI) is a common post-cardiac surgery complication and influences patient morbidity and prognosis. This study was designed to identify preoperative candidate urine biomarkers in patients undergoing cardiac surgery.

methodsA prospective cohort study of adults undergoing cardiac surgery at increased risk for AKI at a single hospital between July 2010 and September 2012 was performed. The primary outcome was the development of AKI, defined as an absolute serum creatinine (SCr) level increase ≥ 0.5 mg/dL or a ≥ 50% relative increase within 72 h of surgery. A secondary outcome was development of AKI defined by Kidney Disease Improving Global Outcomes (KDIGO). Urine collected by voiding within 4 h prior to surgery was used for proteomic analysis and confirmatory enzyme linked immunosorbent assays (ELISAs) studies. Biomarkers were tested for AKI-prediction using Cox and Snell R

resultsForty-seven of 755 patients met screening criteria including 15 with AKI. Proteomic analysis identified 29 proteins with a significant ≥2-fold change. Confirmatory ELISA measurements of five candidate markers showed urinary complement factor B (CFB) and histidine rich glycoprotein (HRG) concentrations were significantly increased in patients with AKI. By multivariate analysis, NRI, and IDI the addition of CFB and HRG to the standard clinical assessment significantly improved risk prediction for the primary outcome. Only HRG was a significant predictor in the 21 patients with AKI defined by KDIGO criteria.

conclusionsPre-operative urine measurement of CFB or HRG significantly enhanced the current post-surgery AKI risk stratification for more restrictive definition of AKI. HRG, but not CFB or clinical risk stratification, predicted AKI defined by KDIGO. The ability of these biomarkers to predict risk for dialysis-requiring AKI or death could not be reliably assessed in our study due to a small number of patients with either outcome.

Indexed as

Acute Kidney InjuryAgedBiomarkersCardiac Surgical ProceduresCohort StudiesFemaleHumansMaleMiddle AgedPostoperative ComplicationsPredictive Value of TestsProspective StudiesRisk FactorsBiomarkersAKIBiomarkerCardiac surgeryPrognosticUrine

Identifiers

PMID29720115
PMCPMC5930948
OpenAlexW2805200330

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.