Evidence map›Paper›PMID 29719870›Full record

ArticlemSystems

Quantifying the Evolutionary Conservation of Genes Encoding Multidrug Efflux Pumps in the ESKAPE Pathogens To Identify Antimicrobial Drug Targets.

Lauren E Brooks, Sabah Ul-Hasan, Benjamin K Chan, Mark J Sistrom

Open access · goldAbstract read
In one paragraph

Article in mSystems. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Occurrence and Variability of the Efflux Pump GeneInternational journal of molecular sciences · 2022
    Article
  5. BacARscan: anBiology methods & protocols · 2022
    Article
  6. Article
  7. Pan-Resistome Insights into the Multidrug Resistance ofAntibiotics (Basel, Switzerland) · 2021
    Article
  8. Review
  9. Review
  10. Article
  11. Clinical microbiology reviews · 2019
    Review
  12. Genetic Diversity ofFrontiers in genetics · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Lauren E BrooksSchool of Natural Sciences, University of California Merced, Merced, California, USA.ORCID https://orcid.org/0000-0003-0951-6727
Sabah Ul-HasanSchool of Natural Sciences, University of California Merced, Merced, California, USA.
Benjamin K ChanDepartment of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, USA.
Mark J SistromSchool of Natural Sciences, University of California Merced, Merced, California, USA.
University of California, Merced · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
6 · The paper itself

Abstract

Increasing rates of antibiotic-resistant bacterial infection are one of the most pressing contemporary global health concerns. The ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and

Indexed as

antibiotic resistancedrug resistance evolutionefflux pumpspathogens

Identifiers

PMID29719870
PMCPMC5904435
OpenAlexW2800255623

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.