ArticlemSystems
Phylogenetic Placement of Exact Amplicon Sequences Improves Associations with Clinical Information.
Article in mSystems. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 320 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
320 citing papers in PubMed.
- Trial
- Trial
- A randomized, double-blind, placebo-controlled trial of soluble corn fiber supplementation for children with asthma.Frontiers in allergy · 2025Trial
- A Mediterranean Diet Pattern Improves Intestinal Inflammation Concomitant with Reshaping of the Bacteriome in Ulcerative Colitis: A Randomised Controlled Trial.Journal of Crohn's & colitis · 2023Trial
- Dietary weight loss-induced improvements in metabolic function are enhanced by exercise in people with obesity and prediabetes.Nature metabolism · 2023Trial
- The Effect of Oral Iron Supplementation on Gut Microbial Composition: a Secondary Analysis of a Double-Blind, Randomized Controlled Trial among Cambodian Women of Reproductive Age.Microbiology spectrum · 2023Trial
- Infant behavioral state and stool microbiome in infants receiving Lactocaseibacillus rhamnosus GG in formula: randomized controlled trial.BMC pediatrics · 2022Trial
- Human gut microbiome as a composite health biomarker.Gut microbes · 2026Article
- Urbanization-Associated Microbial Diversity Loss and Its Impact on Elderly Health: Integrating Environmental and Host Microbiome Dynamics.Environmental microbiology · 2026Article
- Comparative pathogenicity of Ma5 vaccine and a field isolate of the avian infectious bronchitis virus in SPF chickens.Poultry science · 2026Article
- Article
- Age-Related Microbial Differences in Newly Diagnosed Crohn's Disease Reveal the Distinct Enrichment of Oral-Associated Taxa in Pediatric Patients.Gut and liver · 2026Article
- Population-based characterisation of child and adolescent oral bacterial microbiomes.Microbiome · 2026Article
- Diversity, Composition and Resilience of the Root Microbiome of Tomato Plants in a Hydroponic Rockwool System.Environmental microbiology reports · 2026Article
- Enhancing Quercetin Bioavailability Attenuates Aging Phenotypes via the Gut Microbiota-Intestinal Barrier Axis in Aged Mice.Nutrients · 2026Article
- Gut microbiota and fecal 2-methylbutyric acid in coronary heart disease: a cross-sectional study.Scientific reports · 2026Article
- Article
- Oxycodone self-administration and genetic background exert community-specific effects in the gut microbiome.Scientific reports · 2026Article
- Amoxicillin induces gut dysbiosis leading to long term suppression of type-17 immune tone in the lungs.bioRxiv : the preprint server for biology · 2026Article
- Bacterial necromass recycling promotes diversity maintenance in bacterial communities via resource partitioning.Nature ecology & evolution · 2026Article
260 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Recent algorithmic advances in amplicon-based microbiome studies enable the inference of exact amplicon sequence fragments. These new methods enable the investigation of sub-operational taxonomic units (sOTU) by removing erroneous sequences. However, short (e.g., 150-nucleotide [nt]) DNA sequence fragments do not contain sufficient phylogenetic signal to reproduce a reasonable tree, introducing a barrier in the utilization of critical phylogenetically aware metrics such as Faith's PD or UniFrac. Although fragment insertion methods do exist, those methods have not been tested for sOTUs from high-throughput amplicon studies in insertions against a broad reference phylogeny. We benchmarked the SATé-enabled phylogenetic placement (SEPP) technique explicitly against 16S V4 sequence fragments and showed that it outperforms the conceptually problematic but often-used practice of reconstructing
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.