ArticleTranslational neurodegeneration2018
Divergent topological networks in Alzheimer's disease: a diffusion kurtosis imaging analysis.
Article in Translational neurodegeneration, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Microstructural Hippocampal Alterations in Alzheimer's Disease: A Systematic Review and Meta-Analysis of Diffusion Kurtosis Imaging.Brain and behavior · 2025Pooled it
- Investigation of the topological properties of brain structural and functional networks in patients with mild cognitive impairment.Quantitative imaging in medicine and surgery · 2026Article
- Association between perivascular diffusion and white matter microstructural integrity, free water, Aβ burden, and cognition: diffusion tensor vs. kurtosis tensor.Frontiers in aging neuroscience · 2026Article
- Microstructural brain abnormalities and associated neurocognitive dysfunction in obstructive sleep apnea: a pilot study with diffusion kurtosis imaging.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- End-stage renal disease accompanied by mild cognitive impairment: A study and analysis of trimodal brain network fusion.PloS one · 2024Article
- Test-retest reliability of diffusion kurtosis imaging metrics in the healthy adult brain.Neuroimage. Reports · 2022Article
- Topologic Efficiency Abnormalities of the Connectome in Asymptomatic Patients with Leukoaraiosis.Brain sciences · 2022Article
- A Comparative Analysis of White Matter Structural Networks on SCLC Patients After Chemotherapy.Brain topography · 2022Article
- Intravoxel incoherent motion diffusion-weighted imaging in the characterization of Alzheimer's disease.Brain imaging and behavior · 2022Article
- Comparison of brain microstructure alterations on diffusion kurtosis imaging among Alzheimer's disease, mild cognitive impairment, and cognitively normal individuals.Frontiers in aging neuroscience · 2022Article
- Aberrant brain gray matter and functional networks topology in end stage renal disease patients undergoing maintenance hemodialysis with cognitive impairment.Frontiers in neuroscience · 2022Article
- Altered structural and functional connectivity in CSF1R-related leukoencephalopathy.Brain imaging and behavior · 2021Article
- Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases.International journal of molecular sciences · 2021Review
- Frontotemporal Pathology in Motor Neuron Disease Phenotypes: Insights From Neuroimaging.Frontiers in neurology · 2021Review
- Microstructural and Cerebral Blood Flow Abnormalities in Subjective Cognitive Decline Plus: Diffusional Kurtosis Imaging and Three-Dimensional Arterial Spin Labeling Study.Frontiers in aging neuroscience · 2021Article
- White matter alterations in adult with autism spectrum disorder evaluated using diffusion kurtosis imaging.Neuroradiology · 2019Article
- Diffusion MRI Indices and Their Relation to Cognitive Impairment in Brain Aging: The Updated Multi-protocol Approach in ADNI3.Frontiers in neuroinformatics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBrain consists of plenty of complicated cytoarchitecture. Gaussian-model based diffusion tensor imaging (DTI) is far from satisfactory interpretation of the structural complexity. Diffusion kurtosis imaging (DKI) is a tool to determine brain non-Gaussian diffusion properties. We investigated the network properties of DKI parameters in the whole brain using graph theory and further detected the alterations of the DKI networks in Alzheimer's disease (AD).
methodsMagnetic resonance DKI scanning was performed on 21 AD patients and 19 controls. Brain networks were constructed by the correlation matrices of 90 regions and analyzed through graph theoretical approaches.
resultsWe found small world characteristics of DKI networks not only in the normal subjects but also in the AD patients; Grey matter networks of AD patients tended to be a less optimized network. Moreover, the divergent small world network features were shown in the AD white matter networks, which demonstrated increased shortest paths and decreased global efficiency with fiber tractography but decreased shortest paths and increased global efficiency with other DKI metrics. In addition, AD patients showed reduced nodal centrality predominantly in the default mode network areas. Finally, the DKI networks were more closely associated with cognitive impairment than the DTI networks.
conclusionsOur results suggest that DKI might be superior to DTI and could serve as a novel approach to understand the pathogenic mechanisms in neurodegenerative diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.