Evidence map›Paper›PMID 29719713›Full record

ArticleChemical science2018

Multicomponent polysaccharide-protein bioconjugation in the development of antibacterial glycoconjugate vaccine candidates.

Yanira Méndez, Janoi Chang, Ana R Humpierre, Abel Zanuy, Raine Garrido, Aldrin V Vasco, Jessy Pedroso, Darielys Santana, Laura M Rodríguez, Dagmar García-Rivera and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Article
  3. Ugi Four-Component Reactions Using Alternative Reactants.Molecules (Basel, Switzerland) · 2023
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Glycoconjugate vaccines againstBiophysical reviews · 2021
    Review
  11. Review
  12. Total synthesis of the O-antigen repeating unit ofBeilstein journal of organic chemistry · 2021
    Article
  13. Article
  14. Article
  15. Steroid diversification by multicomponent reactions.Beilstein journal of organic chemistry · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 3 countries.

Yanira MéndezCenter for Natural Products Research , Faculty of Chemistry , University of Havana , Zapata y G , Havana 10400 , Cuba . Email: dgr@fq.uh.cu.
Janoi ChangFinlay Institute of Vaccines , Ave 27 Nr. 19805 , Havana 10600 , Cuba . Email: vicente.verez@finlay.edu.cu.
Ana R HumpierreCenter for Natural Products Research , Faculty of Chemistry , University of Havana , Zapata y G , Havana 10400 , Cuba . Email: dgr@fq.uh.cu.
Abel ZanuyFinlay Institute of Vaccines , Ave 27 Nr. 19805 , Havana 10600 , Cuba . Email: vicente.verez@finlay.edu.cu.
Raine GarridoFinlay Institute of Vaccines , Ave 27 Nr. 19805 , Havana 10600 , Cuba . Email: vicente.verez@finlay.edu.cu.
Aldrin V VascoCenter for Natural Products Research , Faculty of Chemistry , University of Havana , Zapata y G , Havana 10400 , Cuba . Email: dgr@fq.uh.cu.
Jessy PedrosoFinlay Institute of Vaccines , Ave 27 Nr. 19805 , Havana 10600 , Cuba . Email: vicente.verez@finlay.edu.cu.
Darielys SantanaFinlay Institute of Vaccines , Ave 27 Nr. 19805 , Havana 10600 , Cuba . Email: vicente.verez@finlay.edu.cu.
Laura M RodríguezFinlay Institute of Vaccines , Ave 27 Nr. 19805 , Havana 10600 , Cuba . Email: vicente.verez@finlay.edu.cu.
Dagmar García-RiveraFinlay Institute of Vaccines , Ave 27 Nr. 19805 , Havana 10600 , Cuba . Email: vicente.verez@finlay.edu.cu.ORCID 0000-0002-2099-1791
Yury ValdésFinlay Institute of Vaccines , Ave 27 Nr. 19805 , Havana 10600 , Cuba . Email: vicente.verez@finlay.edu.cu.
Vicente Vérez-BencomoFinlay Institute of Vaccines , Ave 27 Nr. 19805 , Havana 10600 , Cuba . Email: vicente.verez@finlay.edu.cu.
Daniel G RiveraCenter for Natural Products Research , Faculty of Chemistry , University of Havana , Zapata y G , Havana 10400 , Cuba . Email: dgr@fq.uh.cu.ORCID 0000-0002-5538-1555
Finlay Institute · CUUniversity of Havana · CU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new synthetic strategy for the development of multivalent antibacterial glycoconjugate vaccines is described. The approach comprises the utilization of an isocyanide-based multicomponent process for the conjugation of functionalized capsular polysaccharides of

Identifiers

PMID29719713
PMCPMC5897956
OpenAlexW2785107968

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.